Merck
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資料

860542P

Avanti

Lactosyl(β) Sphingosine (d18:1)

Avanti Polar Lipids 860542P, powder

すべての画像(1)
別名:
D-lactosyl-β1-1′-D-erythro-sphingosine
Empirical Formula (Hill Notation):
C30H57NO12
CAS番号:
109785-20-8
分子量:
623.77
NACRES:
NA.25

形状

powder

包装

pkg of 1 × 5 mg (860542P-5mg)
pkg of 1 × 50 mg (860542P-50mg)

manufacturer/tradename

Avanti Polar Lipids 860542P

lipid type

sphingolipids

輸送温度

dry ice

保管温度

−20°C

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@](N)([H])CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O[C@H](O2)[C@H](O)[C@@H](O)[C@H]([C@H]2CO)O

InChI

1S/C30H57NO12/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20(34)19(31)18-40-29-27(39)25(37)28(22(17-33)42-29)43-30-26(38)24(36)23(35)21(16-32)41-30/h14-15,19-30,32-39H,2-13,16-18,31H2,1H3/b15-14+/t19-,20+,21+,22+,23-,24-,25+,26+,27+,28+,29+,30-/m0/s1

InChI key

MQKSCOKUMZMISB-GPWKTZPCSA-N

類似品目との比較

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当該品目
860537P860495P860659P
Lactosyl(β) Sphingosine (d18:1) Avanti Polar Lipids 860542P, powder

Avanti

860542P

Lactosyl(β) Sphingosine (d18:1)

Galactosyl(β) Sphingosine (d18:1) Avanti Polar Lipids 860537P, powder

Avanti

860537P

Galactosyl(β) Sphingosine (d18:1)

Monomethyl Sphingosine (d18:1) Avanti Polar Lipids 860495P, powder

Avanti

860495P

Monomethyl Sphingosine (d18:1)

sphingosine-1-phosphate-d7 Avanti Polar Lipids 860659P, powder

Avanti

860659P

スフィンゴシン-1-リン酸-d7

packaging

pkg of 1 × 5 mg (860542P-5mg), pkg of 1 × 50 mg (860542P-50mg)

packaging

pkg of 1 × 25 mg (860537P-25mg), pkg of 1 × 5 mg (860537P-5mg)

packaging

pkg of 1 × 5 mg (860495P-5mg)

packaging

pkg of 1 × 1 mg (860659P-1mg)

manufacturer/tradename

Avanti Polar Lipids 860542P

manufacturer/tradename

Avanti Polar Lipids 860537P

manufacturer/tradename

Avanti Polar Lipids 860495P

manufacturer/tradename

Avanti Polar Lipids 860659P

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

詳細

Lactosyl sphingosine is a glycosylsphingosine (Lyso-GSL), which is found in bovine brain white matter extract.

アプリケーション

Lactosyl(β) Sphingosine (d18:1) or D-lactosyl-β1-1′-D-erythro-sphingosine has been used as an internal standard for the quantification of psychosine using tandem mass spectrometry. It may be used to screen lipids that rapidly and reversibly alter transepithelial electrical resistance (TER) or tight junction (TJ) permeability in epithelial tissue. It may also be used as a standard to determine the extent of recovery of lyso-neutral glycosphingolipids (lyso-n-GSLs) from the Sephadex column.

生物化学的／生理学的作用

Lactosyl sphingosine exhibits better hemolytic activity than lysolecithin.

包装

5 mL Amber Glass Screw Cap Vial (860542P-50mg)
5 mL Amber Glass Screw Cap Vial (860542P-5mg)

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

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COAをリクエストする

Dhimankrishna Ghosh et al.
Cell systems, 4(5), 516-529 (2017-04-04)
We present a systems strategy that facilitated the development of a molecular signature for glioblastoma (GBM), composed of 33 cell-surface transmembrane proteins. This molecular signature, GBMSig, was developed through the integration of cell-surface proteomics and transcriptomics from patient tumors in
Amy C Gross et al.
JCI insight, 3(16) (2018-08-24)
Osteosarcoma (OS), a malignant tumor of bone, kills through aggressive metastatic spread almost exclusively to the lung. Mechanisms driving this tropism for lung tissue remain unknown, though likely invoke specific interactions between tumor cells and other cells within the lung
Michael S Marshall et al.
PloS one, 13(2), e0193438-e0193438 (2018-02-27)
α-Synuclein aggregation has been linked to Gaucher's disease (GD) and Krabbe's disease (KD), lysosomal conditions affecting glycosphingolipid metabolism. α-Synuclein pathology has been directly attributed to the dysregulation of glycosphingolipids in both conditions, specifically to increased galactosylsphingosine (psychosine) content in the
Jacques Bodennec et al.
Journal of lipid research, 44(7), 1413-1419 (2003-05-06)
We describe a new method that permits quantification in the pmol to nmol range of three lyso-neutral glycosphingolipids (lyso-n-GSLs), glucosylsphingosine (GlcSph), galactosylsphingosine (GalSph), and lactosylsphingosine, in the same sample as neutral glycosphingolipids (n-GSLs). Lyso-n-GSLs and n-GSLs are initially obtained from
Richard Mair et al.
Cancer research, 78(18), 5408-5418 (2018-07-29)
13C MRI of hyperpolarized [1-13C]pyruvate metabolism has been used in oncology to detect disease, investigate disease progression, and monitor response to treatment with a view to guiding treatment in individual patients. This technique has translated to the clinic with initial
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