Merck
  • 324833M
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324833-M

Millipore

EGFR Inhibitor III

The EGFR Inhibitor III, also referenced under CAS 733009-42-2, controls the biological activity of EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

All Photos(1)
Synonym(s):
EGFR Inhibitor III, N-(4-((3,4-Dichloro-6-fluorophenyl)amino)-quinazolin-6-yl)-2-chloroacetamide
Empirical Formula (Hill Notation):
C16H10Cl3FN4O
CAS Number:
733009-42-2
Molecular Weight:
399.63

アッセイ

≥98% (HPLC)

形状

solid

manufacturer/tradename

Calbiochem®

保管条件

OK to freeze
protect from light

色

yellow

溶解性

DMSO: 100 mg/mL (Use fresh, anhydrous DMSO.)

保管温度

−20°C

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324832539652324732
EGFR Inhibitor III The EGFR Inhibitor III, also referenced under CAS 733009-42-2, controls the biological activity of EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Millipore

324833-M

EGFR Inhibitor III

EGFR Inhibitor II, BIBX1382 The EGFR Inhibitor II, BIBX1382, also referenced under CAS 196612-93-8, controls the biological activity of EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

324832

EGFR Inhibitor II, BIBX1382

PKCβII/EGFR Inhibitor The PKCβII/EGFR Inhibitor, also referenced under CAS 145915-60-2, controls the biological activity of PKCβII/EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

539652

PKCβII/EGFR Inhibitor

ErbB2 Inhibitor II The ErbB2 Inhibitor II, also referenced under CAS 928207-02-7, controls the biological activity of ErbB2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

324732

ErbB2 Inhibitor II

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

form

solid

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

color

yellow

color

yellow

color

orange

color

yellow

solubility

DMSO: 100 mg/mL (Use fresh, anhydrous DMSO.)

solubility

water: 1 mg/mL, DMSO: 25 mg/mL

solubility

DMSO: 20 mg/mL

solubility

DMSO: 50 mg/mL

詳細

A cell-permeable quinazolinyl-chloroacetamide compound that selectively and irreversibly blocks EGFR autophosphorylation with no effect on the expression levels of EGFR, and suppresses leiomyoma and myometrical cell proliferation (IC50 = 0.7 µM and 1.1 µM, respectively). Shown to induce apoptosis and cell cycle arrest, and in combination with Genistein (Cat. No. 345834) completely suppress leiomyoma cell proliferation.
A cell-permeable quinazolinyl-chloroacetamide compound that selectively and irreversibly blocks EGFR autophosphorylation with no effect on the expression levels of EGFR, and suppresses leiomyoma and myometrical cell proliferation (IC50 = 0.7 µM and 1.1 µM, respectively). Shown to induce apoptosis and cell cycle arrest, and in combination with Genistein (Cat. No. 345834) completely suppress leiomyoma cell proliferation.

生物化学的／生理学的作用

Primary Target
EGFR
Target IC50: 0.7 µM and 1.1 µM suppressesing leiomyoma and myometrical cell proliferation, respectively

警告

Toxicity: Irritant (B)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Shushan, A., et al. 2007. Fertil. Steril.87, 127.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

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