345888

JMV 2959

≥97% (HPLC), powder, Ghrelin receptor antagonist, Calbiochem^®

• 別名: Ghrelin Receptor Antagonist, JMV 2959, Growth hormone secretagogue receptor antagonist, (R)-N-(2-(1H-indol-3-yl)-1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)ethyl)-2-aminoacetamide hydrochloride, GHSR1a Antagonist, GH secretagogue receptor antagonist, JMV2959
• 実験式（ヒル表記法）: C₃₀H₃₂N₆O₂ · xHCl
• 分子量: 508.61 (free base basis)
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• Product Name: Ghrelin Receptor Antagonist, JMV 2959,
• アッセイ: ≥97% (HPLC)
• 品質水準: 100
• フォーム: powder
• 有効性: 32 nM IC₅₀
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: beige
• 溶解性: DMSO: 100 mg/mL; water: 5 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C

詳細

詳細

JMV 2959, which blocks the signaling of the growth hormone secretagogue receptor 1A, reduces the deficits in prepulse inhibition induced by the NMDAR antagonist, phencyclidine.[1]

アプリケーション

Ghrelin Receptor Antagonist, JMV 2959 has been used to examine oxytocin receptor (OTR) and ghrelin receptor (GHSR) signaling.[2] It has also been used as a GHS-R1a receptor antagonist to pretreat Hek cells followed by pyridone 8 exposure to study its effect on GHS-R1a receptor-mediated calcium influx.[3]

生物化学的／生理学的作用

Primary Target
Ghrelin receptor

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

物理的形状

Supplied as a hydrochloride salt.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Moulin, A., et al. 2013. Amino Acids44, 301.
Mary, S., et al. 2012. Proc Natl Acad Sci USA109, 8304.
Salome, N., et al. 2009. Eur J Pharmacol.612, 167,.
Moulin, A., et al. 2007. J Med Chem50, 579.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable