Merck
  • 407621
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407621

Sigma-Aldrich

IL-2Rα Antagonist

The IL-2Rα Antagonist, also referenced under CAS 1217448-66-2, controls the biological activity of IL-2Rα.

Synonym(s):
IL-2Rα Antagonist, (R)-N-(2-(1-(Aminoiminomethyl)-3-piperidinyl)-1-oxoethyl)-4-(phenylethynyl)-L-phenylalanine methyl ester, trifluoroacetate, Ro26-4550
Empirical Formula (Hill Notation):
C26H30N4O3 · xC2HF3O2
CAS Number:
Molecular Weight:
446.54 (free base basis)

品質水準

アッセイ

≥95% (HPLC)

形状

solid

manufacturer/tradename

Calbiochem®

保管条件

OK to freeze
desiccated (hygroscopic)
protect from light

white

溶解性

ethanol: 2 mg/mL
DMSO: 28 mg/mL

輸送温度

ambient

保管温度

2-8°C

InChI

1S/C26H30N4O3.C2HF3O2/c1-33-25(32)23(29-24(31)17-22-8-5-15-30(18-22)26(27)28)16-21-13-11-20(12-14-21)10-9-19-6-3-2-4-7-19;3-2(4,5)1(6)7/h2-4,6-7,11-14,22-23H,5,8,15-18H2,1H3,(H3,27,28)(H,29,31);(H,6,7)/t22-,23+;/m1./s1

InChI key

BVMWPONRCOSTMK-RFPXDPOKSA-N

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407616182706616520
IL-2Rα Antagonist The IL-2Rα Antagonist, also referenced under CAS 1217448-66-2, controls the biological activity of IL-2Rα.

Sigma-Aldrich

407621

IL-2Rα Antagonist

IL-1R Antagonist The IL-1R Antagonist, also referenced under CAS 566914-00-9, controls the biological activity of IL-1R.

Sigma-Aldrich

407616

IL-1R Antagonist

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

form

solid

form

oil

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

color

white

color

colorless

color

white

color

yellow

solubility

ethanol: 2 mg/mL, DMSO: 28 mg/mL

solubility

DMSO: 10 mg/mL, ethanol: soluble

solubility

DMSO: 100 mg/mL

solubility

DMSO: 50 mg/mL

詳細

A non-peptidyl acylphenylalanine compound that binds to IL-2 and acts as a competitive inhibitor of the IL-2/IL-2Rα interaction (IC50 = 3 µM).

生物化学的/生理学的作用

Cell permeable: no
Primary Target
Inhibitor of the IL-2/IL-2Rα interaction
Product does not compete with ATP.
Reversible: no
Target IC50: 3 µM against IL-2/IL-2Rα interaction

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Emerson, S.D., et al. 2003. Protein Science12, 811.
Tilley, J.W., et al. 1997. J. Am. Chem. Soc.119, 7589.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

保管分類コード

11 - Combustible Solids

WGK

WGK 1

引火点(°F)

Not applicable

引火点(℃)

Not applicable


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