Merck
  • 410957
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410957

Sigma-Aldrich

3-Isobutyl-1-methylxanthine

A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC₅₀ = 2-50 µM).

All Photos(1)
Synonym(s):
3-Isobutyl-1-methylxanthine, IBMX
Empirical Formula (Hill Notation):
C10H14N4O2
CAS Number:
28822-58-4
Molecular Weight:
222.24
MDL番号:
MFCD00005584

品質水準

100

アッセイ

≥98% (HPLC)

形状

solid

manufacturer/tradename

Calbiochem®

保管条件

OK to freeze

色

white

溶解性

ethanol: 10 mg/mL
DMSO: 100 mM
methanol: 50 mg/mL

輸送温度

ambient

保管温度

−20°C

InChI

1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)

InChI key

APIXJSLKIYYUKG-UHFFFAOYSA-N

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This Item
I5879I70181347802
3-Isobutyl-1-methylxanthine A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC₅₀ = 2-50 µM).

Sigma-Aldrich

410957

3-Isobutyl-1-methylxanthine

3-Isobutyl-1-methylxanthine ≥99% (HPLC), powder

Sigma-Aldrich

I5879

3-イソブチル-1-メチルキサンチン

3-Isobutyl-1-methylxanthine BioUltra, ≥99%

Sigma-Aldrich

I7018

3-イソブチル-1-メチルキサンチン

Isobutyl acetate United States Pharmacopeia (USP) Reference Standard

USP

1347802

酢酸イソブチル

assay

≥98% (HPLC)

assay

≥99% (HPLC)

assay

≥99%

assay

-

form

solid

form

powder

form

-

form

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

-

manufacturer/tradename

USP

storage condition

OK to freeze

storage condition

-

storage condition

-

storage condition

-

color

white

color

white to off-white

color

-

color

-

solubility

ethanol: 10 mg/mL, DMSO: 100 mM, methanol: 50 mg/mL

solubility

DMSO: 1 M (with gentle warming), ethanol: 10 mg/mL

solubility

DMSO: soluble 1 M (with gentle warming)

solubility

-

詳細

A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNF-α expression in adipocyte precursor cells.
A non-specific, cell-permeable inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNFα expression in adipocyte precursor cells.

生物化学的／生理学的作用

Cell permeable: yes
Primary Target
cAMP and cGMP phosphodiesterases
Product does not compete with ATP.
Reversible: no
Target IC50: 2-50 µM against cAMP and cGMP phosphodiesterases

警告

Toxicity: Standard Handling (A)

調製ノート

Heating may be required to achieve complete solubilization.

再構成

Following reconstitution in ethanol or methanol, refrigerate (4°C). Following reconstitution in DMSO, aliquot and freeze (-20°C). Ethanol/methanol and DMSO stock solutions are stable for up to 6 months at 4°C or -20°C, respectively.

その他情報

Hube, F., et al. 1999. Horm. Metab. Res.31, 359.
Morgan, A.J., et al. 1993. Biochem. Pharmacol.45, 2373.
Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119.
Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876.
Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci.11, 150.
Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA76, 4451.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

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