475878

(+)-MK 801 Maleate

A highly potent, selective, and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA-associated ion channel, thus preventing Ca²⁺ flux.

• 別名: (+)-MK 801 Maleate, (5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-10-imine, Maleate, Dizocilpine Maleate, NMDA Antagonist I
• Empirical Formula (Hill Notation): C₁₆H₁₅N · xC₄H₄O₄
• CAS番号: 77086-22-7
• 分子量: 221.30 (free base basis)
• MDL番号: MFCD00082465

特性

• アッセイ: ≥98% (HPLC)
• 形状: solid
• manufacturer/tradename: Calbiochem^®
• 保管条件: OK to freeze; desiccated
• 色: white
• 溶解性: water: 3 mg/mL; ethanol: soluble
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m1./s1
• InChI key: QLTXKCWMEZIHBJ-PJGJYSAQSA-N

詳細

詳細

A highly potent, selective and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA associated ion channel, preventing Ca²⁺ flux. An effective anti-ischemic agent in several animal models. Has been used to develop an in vivo model of NMDA receptor-dependent apoptotic neurodegenerative disease in developing rat brains. Has also been used to develop an in vitro model of NMDA receptor-specific Ca²⁺ entry induced seizures.

A highly potent, selective, and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA-associated ion channel, thus preventing Ca²⁺ flux. An effective anti-ischemic agent in several animal models. Has been used to develop an in vivo model of NMDA receptor-dependent apoptotic neurodegenerative disease in developing rat brains. Has also been used to develop an in vitro model of NMDA receptor-specific Ca²⁺ entry induced seizures.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
NMDA receptor

Reversible: no

警告

Toxicity: Standard Handling (A)

調製ノート

Stock solutions in water may require warming and vigorous stirring to achieve complete solubilization.

再構成

Following reconstitution in water refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Aqueous stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.

その他情報

Ikonomidou, C., et al. 1999. Science 283, 70.
DeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
Woodruff, G.N., et al. 1987. Neuropharmacology 26, 903.
Wong, E.H.F., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 7104.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(℃): Not applicable