553211

Rapamycin

≥95% (HPLC), solution, mTOR inhibitor, Calbiochem

• 別名: InSolution Rapamycin, mTOR Inhibitor I
• 実験式（ヒル表記法）: C₅₁H₇₉NO₁₃
• 分子量: 914.17
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• product name: Rapamycin, Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus
• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solution
• メーカー／製品名: Calbiochem^®
• 保管条件: desiccated (hygroscopic); protect from light
• 輸送温度: wet ice
• 保管温度: −20°C

詳細

詳細

Selectively inhibits the phosphorylation and activation of p70 S6 kinase (IC₅₀ = 50 pM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G₁ phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G₁ phase.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
Mammalian target of rapamycin (mTOR)

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 50 pM inhibiting the mammalian target of rapamycin (mTOR) and blocking the subsequent activation of p70 S6 kinase

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

物理的形状

2.5 mg/mL solution in DMSO (2.74 mM)

再構成

Following initial use, aliquot and freeze (-20°C).

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• 引火点(℃): 87 °C - closed cup - (Dimethylsulfoxide)