565850

Shikonin

A naphthoquinone found in the Chinese herb Shiunko.

• Synonym(s): Shikonin, Pyruvate Kinase Inhibitor II
• Empirical Formula (Hill Notation): C₁₆H₁₆O₅
• CAS Number: 517-89-5
• Molecular Weight: 288.30
• MDL番号: MFCD00075680

Properties

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• manufacturer/tradename: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: red
• 溶解性: DMSO: 10 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C16H16O5/c1-8(2)3-4-10(17)9-7-13(20)14-11(18)5-6-12(19)15(14)16(9)21/h3,5-7,10,17-19H,4H2,1-2H3
• InChI key: NEZONWMXZKDMKF-UHFFFAOYSA-N

Description

詳細

A naphthoquinone found in the Chinese herb Lithospermum erythrorhizon. Possesses significant antibacterial, anti-inflammatory and antitumor activities. Inhibits TNF-α and B-16 melanoma-induced angiogenesis in mice. Blocks the expression of integrin αVβ3 and inhibits endothelial cells proliferation and migration in vitro. Also induces apoptosis in HL60 human promyelocytic leukemia cell line. Selectively blocks PKM2 (IC₅₀<1 µM) over PKM1 and PKL activities (IC₅₀ in the range of 10-20 µM), and inhibits cancer cell glycolysis.

A naphthoquinone found in the Chinese herb Shiunko. Possesses significant antibacterial, anti-inflammatory, and antitumor activities. Inhibits TNF-α-induced and B-16 melanoma-induced angiogenesis in mice. Blocks the expression of integrin α_vβ₃ and inhibits endothelial cell proliferation and migration in vitro. Also induces apoptosis in HL60 human promyelocytic leukemia cell line.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
TNF-α-induced and B-16 melanoma-induced angiogenesis

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Chen, J., et al. 2011. Oncogene30, 4297.
Li, H., et al. 1999. Phytother. Res.13, 236.
Yoon, Y., et al. 1999. Planta Med.65, 532.
Hisa, T., et al. 1998. Anticancer Res. 18, 783.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable