Merck
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資料

574215

Sigma-Aldrich

D,L-Sulforaphane

An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.

すべての画像(1)
別名:
D,L-Sulforaphane, 1-Isothiocyanato-4-(methylsulfinyl)butane, R,S-Sulforaphane
Empirical Formula (Hill Notation):
C6H11NOS2
CAS番号:
4478-93-7
分子量:
177.29
MDL番号:
MFCD00198068
NACRES:
NA.77

品質水準

100

アッセイ

≥98% (UPLC)

形状

liquid

manufacturer/tradename

Calbiochem®

保管条件

OK to freeze
protect from light

色

slight yellow

溶解性

ethanol: 10 mg/mL
DMSO: 20 mg/mL

輸送温度

ambient

保管温度

−20°C

InChI

1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3

InChI key

SUVMJBTUFCVSAD-UHFFFAOYSA-N

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当該品目
S4441574102S6317
D,L-Sulforaphane An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.

Sigma-Aldrich

574215

D,L-Sulforaphane

DL-Sulforaphane ≥90% (HPLC), synthetic, liquid

Sigma-Aldrich

S4441

DL-スルホラファン

Sulindac Sulfide A cell-permeable, active metabolite of Sulindac.

Sigma-Aldrich

574102

Sulindac Sulfide

L-Sulforaphane ≥95% (HPLC), oil

Sigma-Aldrich

S6317

L-スルフォラファン

form

liquid

form

liquid

form

solid

form

oil

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

storage condition

OK to freeze, protect from light

storage condition

-

storage condition

OK to freeze

storage condition

-

color

slight yellow

color

-

color

yellow-orange

color

light yellow

solubility

ethanol: 10 mg/mL, DMSO: 20 mg/mL

solubility

DMSO: soluble 40 mg/mL, H2O: insoluble

solubility

DMSO: 25 mg/mL, ethanol: 5 mg/mL

solubility

DMSO: >5 mg/mL

詳細

An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. It has been shown to be an effective agent in prevention of chemically-induced mammary tumors in rats. It also inhibits the phase I cytochrome P450 isoenzymes 2E1 and IA2 which have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by mitogen-activated protein kinase (MAPK) pathway.
An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. Shown to be an effective agent in prevention of chemically-induce mammary tumors in rats. Also shown to inhibit the phase I cytochrome P450 isoenzymes 2E1 and IA2 that have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by the mitogen-activated protein kinase (MAPK) pathway.

生物化学的／生理学的作用

Cell permeable: no
Primary Target
Potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture
Product does not compete with ATP.
Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze DMSO stock solutions (-20°C) and ethanol stock solutions (-70°C). DMSO stock solutions are stable for up to 3 months at -20°C and ethanol stock solutions are stable for up to 3 months at -70°C.

その他情報

Gamet-Payrastre, L., et al. 2000. Cancer Res.60, 1426.
Yu, R., et al. 2000. J. Biol. Chem.275, 2322.
Yu, R., et al. 1999. J. Biol. Chem.274, 27545.
Barcelo, S., et al. 1998. Mutat. Res.402, 111.
Maheo, K., et al. 1997. Cancer Res.57, 3649.
Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA91, 3147.
Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA89, 2399.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

保管分類コード

10 - Combustible liquids

WGK

WGK 3

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ドキソルビシン 塩酸塩

Jessica Gasparello et al.
Nucleic acid therapeutics, 30(3), 164-174 (2020-02-19)
Sulforaphane (SFN) is one of most important dietary constituents of broccoli (Brassica oleracea) and other cruciferous vegetables, which have been reported to exhibit health benefits, including prevention and therapy of cancer, such as colorectal carcinoma (CRC). The objective of this
Amanda Swain et al.
Nature metabolism, 2(7), 594-602 (2020-07-23)
Following activation, macrophages undergo extensive metabolic rewiring1,2. Production of itaconate through the inducible enzyme IRG1 is a key hallmark of this process3. Itaconate inhibits succinate dehydrogenase4,5, has electrophilic properties6 and is associated with a change in cytokine production4. Here, we
Yuting Yan et al.
Cell death & disease, 12(10), 917-917 (2021-10-09)
We previously demonstrated that sulforaphane (SFN) inhibited autophagy leading to apoptosis in human non-small cell lung cancer (NSCLC) cells, but the underlying subcellular mechanisms were unknown. Hereby, high-performance liquid chromatography-tandem mass spectrometry uncovered that SFN regulated the production of lipoproteins
Eslam Mohamed et al.
Immunity, 52(4), 668-682 (2020-04-16)
The primary mechanisms supporting immunoregulatory polarization of myeloid cells upon infiltration into tumors remain largely unexplored. Elucidation of these signals could enable better strategies to restore protective anti-tumor immunity. Here, we investigated the role of the intrinsic activation of the

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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