Merck
  • 676491
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676491

Sigma-Aldrich

VEGF Inducer, GS4012

A cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation.

All Photos(1)
Synonym(s):
VEGF Inducer, GS4012, 4-(2-(4-Methoxyphenylsulfanyl)ethyl)pyridine, HCl, GS4012
Empirical Formula (Hill Notation):
C14H15NOS · xHCl
CAS Number:
328073-92-3
Molecular Weight:
245.34 (free base basis)

品質水準

100

アッセイ

≥97% (HPLC)

形状

solid

manufacturer/tradename

Calbiochem®

保管条件

OK to freeze
desiccated (hygroscopic)
protect from light

色

white

溶解性

DMSO: 200 mg/mL
methanol: 50 mg/mL
water: soluble

輸送温度

ambient

保管温度

2-8°C

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VEGF Inducer, GS4012 A cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation.

Sigma-Aldrich

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Sigma-Aldrich

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assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

form

solid

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

color

white

color

yellow

color

off-white

color

red

solubility

DMSO: 200 mg/mL, methanol: 50 mg/mL, water: soluble

solubility

DMSO: 100 mg/mL (Use fresh, anhydrous DMSO.)

solubility

DMSO: 5 mg/mL

solubility

DMSO: 10 mg/mL

詳細

A cell-permeable and potent inducer of VEGF and VEGF-mediated blood vessel formation. GS4012-induced upregulation of VEGF correlates with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish and to stimulate tubule network formation (5 µg/ml) in HUVECs. An essential molecule required during angioblasts cell fate determination.
A cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation. GS4012-induced upregulation of VEGF correlates well with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish and to stimulate tubule network formation (5 µg/ml) in HUVECs.

生物化学的／生理学的作用

Cell permeable: yes
Primary Target
Potent inducer of VEGF and VEGF-mediated vessel formation
Product does not compete with ATP.
Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Peterson, R.T., et al. 2004. Nat. Biotechnol.22, 595.
Depre, C., et al. 2003. Circulation108, 2723.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

保管分類コード

11 - Combustible Solids

WGK

WGK 1

引火点(°F)

Not applicable

引火点(℃)

Not applicable

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