Merck

AB16942

Sigma-Aldrich

Anti-DR5 Antibody, CT

Chemicon®, from rabbit

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別名:
Anti-CD262, Anti-DR5, Anti-KILLER, Anti-KILLER/DR5, Anti-TRAIL-R2, Anti-TRAILR2, Anti-TRICK2, Anti-TRICK2A, Anti-TRICK2B, Anti-TRICKB, Anti-ZTNFR9
eCl@ss:
32160702
NACRES:
NA.41

由来生物

rabbit

品質水準

抗体製品の状態

affinity purified immunoglobulin

antibody product type

primary antibodies

クローン

polyclonal

分子量

calculated mol wt-47.88 kDa
observed mol wt ~55 kDa

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

western blot: suitable

NCBIアクセッション番号

UniProtアクセッション番号

輸送温度

wet ice

target post-translational modification

unmodified

Gene Information

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当該品目
SAB3500427SAB4700540HPA023625
Anti-DR5 Antibody, CT Chemicon®, from rabbit

Sigma-Aldrich

AB16942

Anti-DR5 Antibody, CT

antibody form

affinity purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

clone

polyclonal

clone

polyclonal

clone

DR5-01-1, monoclonal

clone

polyclonal

mol wt

calculated mol wt-47.88 kDa, observed mol wt ~55 kDa

mol wt

-

mol wt

-

mol wt

-

species reactivity

human

species reactivity

human, mouse

species reactivity

human

species reactivity

human

manufacturer/tradename

Chemicon®

manufacturer/tradename

-

manufacturer/tradename

-

manufacturer/tradename

-

特異性

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2 or KILLER by several groups independently (Pan et al. 1997; Sheridan et al. 1997; Walczak et al. 1997; MacFarlane et al. 1997; Screaton et al. 1997; Wu et al. 1997; Chaudhary et al. 1997). Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.

免疫原

Epitope: C-terminus
Polyclonal antibody raised against a peptide corresponding to amino acids 388-407 of human DR5 precursor (Pan et al. 1997; Sheridan et al. 1997).

アプリケーション

Research Category
アポトーシス及び癌
Research Sub Category
アポトーシス-追加
Anti-DR5 Antibody, C-terminus detects level of DR5 & has been published & validated for use in WB.
Western blot: 1:250 to 1:500

Whole cell lysate from HeLa or K562 cells can be used as a positive control .

Optimal working dilutions must be determined by end user.

物理的形状

Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.
Format: Purified

保管および安定性

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.

その他情報

Click here for more information on observed vs. calculated molecular weight.


Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法的情報

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

保管分類コード

10 - Combustible liquids

WGK

WGK 2

引火点(°F)

Not applicable

引火点(℃)

Not applicable


Certificates of Analysis (COA)

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COAをリクエストする

Mohammed I Y Elmallah et al.
Oncology reports, 37(6), 3635-3642 (2017-04-26)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent, as it can kill tumor cells selectively. In our search of bioactive natural products to overcome TRAIL-resistance, we isolated 47 actinomycete strains from different sediments and seawater samples collected
Mini Jeong et al.
International journal of molecular sciences, 24(2) (2023-01-22)
Rheumatoid arthritis (RA) is an inflammatory disease marked by a massive proliferation of synovial cells in the joints. In this study, we investigated the pro-apoptotic effects of docosahexaenoic acid (DHA) in human fibroblast-like synovial cells from RA patients (RA-FLS). An
Florent Dufour et al.
Oncotarget, 8(6), 9974-9985 (2017-01-01)
TRAIL induces selective tumor cell death through TRAIL-R1 and TRAIL-R2. Despite the fact that these receptors share high structural homologies, induction of apoptosis upon ER stress, cell autonomous motility and invasion have solely been described to occur through TRAIL-R2. Using
Dmitri V Rozanov et al.
Molecular cancer therapeutics, 8(6), 1515-1525 (2009-06-11)
Successful cancer therapies aim to induce selective apoptosis in neoplastic cells. The current suboptimal efficiency and selectivity drugs have therapeutic limitations and induce concomitant side effects. Recently, novel cancer therapies based on the use of tumor necrosis factor-related apoptosis-inducing ligand
Characterization of BV6-Induced Sensitization to the NK Cell Killing of Pediatric Rhabdomyosarcoma Spheroids.
S??rchen, et al.
Cells, 12 (2023)

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