Merck

AB16955

Sigma-Aldrich

Anti-DR4 Antibody, CT

Chemicon®, from rabbit

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別名:
TRAIL-R1
eCl@ss:
32160702
NACRES:
NA.41

由来生物

rabbit

品質水準

抗体製品の状態

affinity purified immunoglobulin

antibody product type

primary antibodies

クローン

polyclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

western blot: suitable

NCBIアクセッション番号

UniProtアクセッション番号

輸送温度

wet ice

target post-translational modification

unmodified

Gene Information

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当該品目
SAB3500428SAB4700541SAB4701084
Anti-DR4 Antibody, CT Chemicon®, from rabbit

Sigma-Aldrich

AB16955

Anti-DR4 Antibody, CT

antibody form

affinity purified immunoglobulin

antibody form

IgG fraction of antiserum

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

clone

polyclonal

clone

polyclonal

clone

DR-4-02, monoclonal

clone

DR-4-02, monoclonal

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

-

manufacturer/tradename

Chemicon®

manufacturer/tradename

-

manufacturer/tradename

-

manufacturer/tradename

-

technique(s)

western blot: suitable

technique(s)

immunocytochemistry: suitable, immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

technique(s)

flow cytometry: suitable, immunocytochemistry: suitable, immunoprecipitation (IP): suitable

technique(s)

flow cytometry: 1 μg/mL

特異性

Apoptosis, or programmed cell death, occurs during normal cellular diffferentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR4 (for death receptor 4) (Pan et al. 1997). The ligand for this novel cell death receptor has been identified and termed TRAIL, which is a new member in TRF family. Therefore, DR4 is also called TRAIL receptor-1 (TRAIL-R1) (Schneider et al. 1997). DR4 is expresssed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates TRAIL induced apoptosis and NF-kB activation in many tissues and cells.

免疫原

Epitope: C-terminus
Polyclonal antibody raised against a peptide corresponding to amino acids 427-445 at C-terminus of human DR4 mature protein.

アプリケーション

Research Category
アポトーシス及び癌
Research Sub Category
アポトーシス-追加
Detect DR4 using this Anti-DR4 Antibody, C-terminus validated for use in WB.
Western blot: 1:500-1:1000

Whole cell lysate from HeLa cells can be used as a positive control and a 57 kDa band should be detected.

Optimal working dilutions must be determined by end user.

物理的形状

Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.
Format: Purified

保管および安定性

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法的情報

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

保管分類コード

10 - Combustible liquids

WGK

WGK 2

引火点(°F)

Not applicable

引火点(℃)

Not applicable


Certificates of Analysis (COA)

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COAをリクエストする

V Pavet et al.
Cell death & disease, 5, e1043-e1043 (2014-02-01)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/TNFSF10/Apo2L) holds promise for cancer therapy as it induces apoptosis in a large variety of cancer cells while exerting negligible toxicity in normal ones. However, TRAIL can also induce proliferative and migratory signaling in cancer
Doaa Tawfik et al.
Frontiers in immunology, 10, 2044-2044 (2019-09-27)
Acquired immune evasion is one of the mechanisms that contributes to the dismal prognosis of cancer. Recently, we observed that different γδ T cell subsets as well as CD8+ αβ T cells infiltrate the pancreatic tissue. Interestingly, the abundance of
Mohammed I Y Elmallah et al.
Oncology reports, 37(6), 3635-3642 (2017-04-26)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent, as it can kill tumor cells selectively. In our search of bioactive natural products to overcome TRAIL-resistance, we isolated 47 actinomycete strains from different sediments and seawater samples collected
Anna Willms et al.
PloS one, 14(4), e0214847-e0214847 (2019-04-05)
Due to their ability to preferentially induce cell death in tumor cells, while sparing healthy cells, TNF-related apoptosis-inducing ligand (TRAIL) and agonistic anti-TRAIL-R1 or anti-TRAIL-R2-specific antibodies are under clinical investigations for cancer-treatment. However, TRAIL-Rs may also induce signaling pathways, which
Florent Dufour et al.
Oncotarget, 8(6), 9974-9985 (2017-01-01)
TRAIL induces selective tumor cell death through TRAIL-R1 and TRAIL-R2. Despite the fact that these receptors share high structural homologies, induction of apoptosis upon ER stress, cell autonomous motility and invasion have solely been described to occur through TRAIL-R2. Using

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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