31550

2,3-ブタンジオンモノオキシム

for spectrophotometric det. of urea, ≥99.0%

• 別名: BDM, ジアセチルモノオキシム, ビアセチルモノキシム
• 化学式: CH₃C(=NOH)COCH₃
• CAS番号: 57-71-6
• 分子量: 101.10
• UNSPSC Code: 41116105
• NACRES: NA.21
• PubChem Substance ID: 329753805
• EC Number: 200-348-5
• Beilstein/REAXYS Number: 605582
• MDL number: MFCD00002116
• Assay: ≥98.0% (N), ≥99.0%
• Form: solid
• Quality level: 100

特性

• Quality Level: 100
• assay: ≥98.0% (N), ≥99.0%
• form: solid
• quality: for spectrophotometric det. of urea
• technique(s): UV/Vis spectroscopy: suitable
• ign. residue: ≤0.05% (as SO₄)
• bp: 185-186 °C (lit.)
• mp: 75-76 °C, 75-78 °C (lit.)
• SMILES string: CC(=O)\C(C)=N\O
• InChI: 1S/C4H7NO2/c1-3(5-7)4(2)6/h7H,1-2H3/b5-3+
• InChI key: FSEUPUDHEBLWJY-HWKANZROSA-N

詳細

General description

2,3-Butanedione Monoxime (BDM) is also known as diacetyl monoxime, it is also a nucleophilic agent and it can dephosphorylates acetylcholinesterase poisoned with organophosphates. It is also a well-characterized, non-competitive inhibitor of skeletal muscle myosin-II, where it inhibits the chemical and motile activity.

Application

• A novel method to extend viability and functionality of living heart slices.: This research introduces a novel application of 2,3-Butanedione monoxime for prolonging the functional lifespan of cardiac tissue samples in experimental settings, offering insights into cardiac biology and potential therapeutic targets (Ross et al., 2023).


• Molecular Mechanisms of Deregulation of Muscle Contractility Caused by the R168H Mutation in TPM3 and Its Attenuation by Therapeutic Agents.: The study utilizes 2,3-Butanedione monoxime to investigate the molecular pathways affected by genetic mutations in muscle contractility, contributing to the understanding of muscle disorders and their management (Karpicheva et al., 2023).


• Generation of myocyte agonal Ca(2+) waves and contraction bands in perfused rat hearts following irreversible membrane permeabilisation.: Research employing 2,3-Butanedione monoxime investigates its role in inducing specific cellular events in cardiac cells under stress, highlighting its potential in studies of heart disease mechanisms and therapies (Morishita et al., 2023).

Analysis Note

溶解度:
10 mLの水または10 mLのエタノールに0.5 gが完全に溶解し、透明溶液となります。
感度分析:
0.05 mgの尿素を3 mLの水、5 mL濃塩酸、3%ジアセチルモノキシム水溶液とともに水浴で10分間加熱すると、淡黄色の溶液が得られます。

Other Notes

Reagent for the colorimetric determination of urea and ureido-compounds; Spectrometric reagent for Co(II), Ni(II), Pd(II) and Re(VII); Reagent for the gravimetric determination of Ni(II)

安全性情報

• 保管分類: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)