PHR1004

イブプロフェン

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): α-メチル-4-(イソブチル)フェニル酢酸, (±)-2-(4-イソブチルフェニル)プロパン酸
• Empirical Formula (Hill Notation): C₁₃H₁₈O₂
• CAS Number: 15687-27-1
• Molecular Weight: 206.28
• EC 番号: 239-784-6
• MDL番号: MFCD00010393
• PubChem Substance ID: 329823035

Properties

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to BP 539; traceable to Ph. Eur. I0020000; traceable to USP 1335508
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: 2-30°C
• SMILES string: CC(C)Cc1ccc(cc1)C(C)C(O)=O
• InChI: 1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
• InChI key: HEFNNWSXXWATRW-UHFFFAOYSA-N
• Gene Information: human ... PTGS1(5742) , PTGS2(5743)

Description

詳細

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Ibuprofen is a substituted arylpropionic acid, used as a non-steroidal anti-inflammatory drug (NSAID).

アプリケーション

Ibuprofen may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry and chromatography techniques.

Ibuprofen may be used as a standard in the quantitative determination of ibuprofen in samples of human plasma using high performance liquid chromatography (HPLC). It may also be used as a reference standard in the determination of ibuprofen in dog plasma using liquid chromatography (LC).

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

包装

1 g

生物化学的／生理学的作用

シクロオキシゲナーゼ (COX) のインヒビターであり、COX-2よりもCOX-1に対して強く作用します。

Cyclooxygenase (COX) inhibitor that has greater activity against COX-1 than against COX-2.

アナリシスノート

このような2次標準は、USP、EP（PhEur）、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAC0253 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302 - H319 - H335
• 注意書き: P261 - P264 - P270 - P271 - P301 + P312 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3