PHR1014

ヒドロコルチゾン

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: 11β,17α,21-トリヒドロキシプレグナ-4-エン-3,20-ジオン, 17-ヒドロキシコルチコステロン, 4-プレグネン-11β,17α,21-トリオール-3,20-ジオン, ケンダルコンパウンドF, コルチゾール, ライヒシュタインサブスタンスM
• 実験式（ヒル表記法）: C₂₁H₃₀O₅
• CAS番号: 50-23-7
• 分子量: 362.46
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329823045
• EC Number: 200-020-1
• Beilstein/REAXYS Number: 1354819
• MDL number: MFCD00011654

特性

• Quality Level: 300
• grade: certified reference material, pharmaceutical secondary standard
• agency: traceable to Ph. Eur. H1300000, traceable to USP 1316004
• API family: hydrocortisone
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable, gas chromatography (GC): suitable
• mp: 211-214 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
• InChI: 1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
• InChI key: JYGXADMDTFJGBT-VWUMJDOOSA-N
• Gene Information: human ... NR3C1(2908)

詳細

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Hydrocortisone is a degradation product of the corticosteroid, hydrocortisone acetate.

Application

Hydrocortisone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

副腎皮質から分泌される主要なグルココルチコイドです。

副腎皮質から分泌される主要なグルココルチコイドです。コルチコステロンの3倍の抗炎症作用がありますが、Na⁺ 保持力は非常に低いです。

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.

Analysis Note

このような2次標準は、USP、EP（PhEur）、BPの1次標準にマルチトレーサビリティを提供します。

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAB3713 in the slot below. This is an example certificate only and may not be the lot that you receive.

安全性情報

• pictograms: GHS08
• signalword: Danger
• hcodes: H360Df,H373
• pcodes: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1A - STOT RE 2
• target_organs: Adrenal gland,Bone marrow
• 保管分類: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• flash_point_f: Not applicable
• flash_point_c: Not applicable