PHR1391

プラジクアンテル

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: プラジクアンテル, 2-(シクロヘキシルカルボニル)-1,2,3,6,7-11b-ヘキサヒドロ-4H-ピラジノ[2,1-aイソキノリン-4-オン
• Empirical Formula (Hill Notation): C₁₉H₂₄N₂O₂
• CAS番号: 55268-74-1
• 分子量: 312.41
• Beilstein: 761557
• EC Number: 259-559-6
• MDL番号: MFCD00058531
• PubChem Substance ID: 329823365
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to Ph. Eur. P2670000; traceable to USP 1554603
• API family: praziquantel
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: 2-8°C
• SMILES string: O=C1CN(CC2N1CCc3ccccc23)C(=O)C4CCCCC4
• InChI: 1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2
• Inchi Key: FSVJFNAIGNNGKK-UHFFFAOYSA-N

詳細

詳細

Praziquantel is at present the only drug used for the treatment of human schistosomiasis. It has a pyrazino isoquinoline ring system and is found to be very successful in animals for its anticestode and antitrematode properties. It has been identified that the voltage-gated schistosome calcium ion (Ca²⁺) channels serve as a target for praziquantel. Even though the commercial preparation of praziquantel comprises of equal amounts of both its ‘dextro′ and ‘laevo′ isomers, only the ‘laevo′ form exhibits schistosomicidal activity.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

アプリケーション

Praziquantel may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical preparations by electrochemical, spectrophotometric, and chromatographic techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

脚注

To see an example of a Certificate of Analysis for this material enter LRAA1898 in the slot below. This is an example certificate only and may not be the lot that you receive.

安全性情報

• 危険有害性情報: H412
• 注意書き: P273
• 危険有害性の分類: Aquatic Chronic 3
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1