PHR1437

テモゾロミド

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): テモゾロミド, 3,4-ジヒドロ-3-メチル-4-オキソイミダゾ[5,1-d]-1,2,3,5-テトラジン-8-カルボキサミド, 3-メチル-4-オキソ-8-イミダゾロ[5,1-d][1,2,3,5]テトラジンカルボキサミド, 4-メチル-5-オキソ-2,3,4,6,8-ペンタアザビシクロ[4.3.0]ノナ-2,7,9-トリエン-9-カルボキサミド, 8-カルバモイル-3-メチルイミダゾ[5,1-d]-1,2,3,5-テトラジン-4(3H)-オン, NSC 362856
• Empirical Formula (Hill Notation): C₆H₆N₆O₂
• CAS Number: 85622-93-1
• Molecular Weight: 194.15
• MDL番号: MFCD00866492
• PubChem Substance ID: 329822600
• NACRES: NA.24

Properties

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to USP 1643543
• API family: temozolomide
• CofA: current certificate can be downloaded
• 包装: pkg of 1 g
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: 2-8°C
• SMILES string: CN1N=Nc2c(ncn2C1=O)C(N)=O
• InChI: 1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
• InChI key: BPEGJWRSRHCHSN-UHFFFAOYSA-N

Description

詳細

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.
Temozolomide is an alkylating agent of the imidazotetrazine group. It is a chemotherapy drug, used in the treatment of anaplastic astrocytoma, glioblastoma multiforme and malignant metastatic melanoma, which works by arresting cancer cell growth.

アプリケーション

Temozolomide may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by reverse phase liquid chromatography and UV spectrophotometry.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

アナリシスノート

このような2次標準は、入手可能な場合にはUSP、EP、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAA2745 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• ピクトグラム: GHS07,GHS08
• シグナルワード: Danger
• 危険有害性情報: H302 - H315 - H319 - H335 - H340 - H350 - H360FD
• 注意書き: P202 - P261 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• 危険有害性の分類: Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3