Merck
  • S0929
All Photos(3)

S0929

Sigma-Aldrich

スコポラミン 臭化水素酸塩

meets USP testing specifications

Synonym(s):
(−)-スコポラミン 臭化水素酸塩 三水和物, トロパ酸スコピン, ヒヨスチン 臭化水素酸塩
Empirical Formula (Hill Notation):
C17H21NO4 · HBr · 3H2O
CAS Number:
Molecular Weight:
438.31
Beilstein:
6100669
MDL番号:
PubChem Substance ID:
NACRES:
NA.21

認証

USP/NF
meets USP testing specifications

品質水準

mp

195-199 °C (dry matter) (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

O.O.O.Br.CN1[C@@H]2C[C@H](C[C@H]1[C@@H]3O[C@H]23)OC(=O)[C@H](CO)c4ccccc4

InChI

1S/C17H21NO4.BrH.3H2O/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;;;;/h2-6,11-16,19H,7-9H2,1H3;1H;3*1H2/t11-,12-,13-,14+,15-,16+;;;;/m1..../s1

InChI key

LACQPOBCQQPVIT-SEYKEWMNSA-N

Gene Information

human ... CHRM1(1128)

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This Item
C0857PHR1470H2910
Quality Level

200

Quality Level

300

Quality Level

300

Quality Level

200

agency

USP/NF

agency

USP/NF, meets USP testing specifications

agency

traceable to BP 199, traceable to Ph. Eur. H1500000, traceable to USP 1610001

agency

USP/NF, meets USP testing specifications

mp

195-199 °C (dry matter) (lit.)

mp

148-150 °C (lit.)

mp

-

mp

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

Gene Information

human ... CHRM1(1128)

Gene Information

human ... CYP1A2(1544)

Gene Information

human ... CHRM1(1128)

Gene Information

human ... ALB(213), CA1(759), CA2(760), CA4(762), SLC12A3(6559)

アプリケーション

スコポラミン臭化水素酸塩はムスカリン受容体拮抗薬として、次の用途で使用されます。
  • ウサギの心臓におけるフィゾスチグミンの心臓への影響を反転させるため
  • 音驚愕反射(gap-PPI)に対する効果を研究するため(148)
  • in vitro試験において、抗ウイルス作用、抗菌作用、抗真菌作用および細胞毒性を研究するため
  • レバー押しによる条件付けに対する効果を研究するため

生物化学的/生理学的作用

ムスカリン性アセチルコリンレセプターの非選択的な競合性アンタゴニストです。スコポラミン誘発健忘症の実験動物は、記憶障害のモデルとして広く用いられています。

ピクトグラム

Skull and crossbones

シグナルワード

Danger

危険有害性情報

危険有害性の分類

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

保管分類コード

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 1

引火点(°F)

Not applicable

引火点(℃)

Not applicable

個人用保護具 (PPE)

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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