Merck
All Photos(1)

SMB00950

Sigma-Aldrich

O-Desmethyl gefitinib

≥95%

Synonym(s):
4-[(3-Chloro-4-fluorophenyl)amino]-6-[3-(4-morpholinyl)propoxy]-7-quinazolinol, O-Desmethylgefitinib
Empirical Formula (Hill Notation):
C21H22ClFN4O3
CAS Number:
Molecular Weight:
432.88

由来生物

synthetic

品質水準

グレード

research grade

アッセイ

≥95%

形状

solid

technique(s)

HPLC: suitable

light yellow to yellow

保管温度

−20°C

InChI

1S/C21H22ClFN4O3/c22-16-10-14(2-3-17(16)23)26-21-15-11-20(19(28)12-18(15)24-13-25-21)30-7-1-4-27-5-8-29-9-6-27/h2-3,10-13,28H,1,4-9H2,(H,24,25,26)

InChI key

IFMMYZUUCFPEHR-UHFFFAOYSA-N

Compare Similar Items

View Full Comparison

1 of 4

This Item
SMB00958207713524417
assay

≥95%

assay

≥95%

assay

99%

assay

98%

biological source

synthetic

biological source

synthetic

biological source

-

biological source

-

grade

research grade

grade

research grade

grade

-

grade

-

form

solid

form

-

form

solid

form

-

technique(s)

HPLC: suitable

technique(s)

HPLC: suitable

technique(s)

-

technique(s)

-

color

light yellow to yellow

color

-

color

-

color

-

詳細

O-Desmethyl gefitinib is a major active metabolite of gefitinib. It is a potent EGFR (erbB1/HER1) inhibitor (IC50 = 36 nM). Gefitinib is metabolized by CYP2D6 to O-Desmethyl gefitinib. Gefitinib is an EGFR inhibitor that is used to treat some types of cancers.

アプリケーション

Metabolomics research

ピクトグラム

Exclamation mark

シグナルワード

Warning

危険有害性情報

危険有害性の分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

ターゲットの組織

Respiratory system

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (Example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service