A1487

AG-205

≥98% (HPLC)

• Synonym(s): cis-2-[[1-(4-クロロフェニル)-1H-テトラゾール-5-イル]チオ]-1-(1,2,3,4,4a,9b-ヘキサヒドロ-2,8-ジメチル-5H-ピリド[4,3-b]インドール-5-イル)-エタノン, cis-5-({[1-(4-クロロフェニル)-1H-テトラアゾール-5-イル]スルファニル}アセチル)-2,8-ジメチル-2,3,4,4a,5,9b-ヘキサヒドロ-1H-ピリド[4,3-b]インドール
• Empirical Formula (Hill Notation): C₂₂H₂₃ClN₆OS
• Molecular Weight: 454.98
• PubChem Substance ID: 329770709
• NACRES: NA.77

Properties

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 保管条件: desiccated
• 色: off-white to brown
• 溶解性: DMSO: >9 mg/mL (warmed)
• 保管温度: 2-8°C
• SMILES string: CN1CC[C@@H]2[C@H](C1)c3cc(C)ccc3N2C(=O)CSc4nnnn4-c5ccc(Cl)cc5
• InChI: 1S/C22H23ClN6OS/c1-14-3-8-19-17(11-14)18-12-27(2)10-9-20(18)28(19)21(30)13-31-22-24-25-26-29(22)16-6-4-15(23)5-7-16/h3-8,11,18,20H,9-10,12-13H2,1-2H3/t18-,20-/m1/s1
• InChI key: GJNBAISSZRNGTM-UYAOXDASSA-N

Description

アプリケーション

AG-205 has been used to investigate the neuroprotective effects of norgestrel on stressed photoreceptors. It has also been used to study the effect of blocking progesterone receptor membrane component 1 in 661W cells.

生物化学的／生理学的作用

AG-205は、プロゲステロン受容体 膜成分1(Pgrmc1)阻害剤です。AG-205は、Pgrmc1-ヘム複合体の分光学的特性を変化させます。AG-205は、癌細胞の生存能と癌細胞の進行を阻害します。Pgrmc1を発現する細胞に優先的に作用します。

Pgrmc1 is a cytochrome associated protein. It is found to be upregulated in several cancer types such as breast, lung and gastric cancer. Pgrmc1 regulates the epidermal growth factor signaling.

特徴および利点

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable