Merck
すべての画像(1)

資料

A3109

Sigma-Aldrich

A-803467

≥98% (HPLC)

すべての画像(1)
別名:
5-4(-クロロフェニル)-N-(3,5-ジメトキシフェニル)フラン-2-カルボキサミド
Empirical Formula (Hill Notation):
C19H16NO4Cl
CAS番号:
944261-79-4
分子量:
357.79
MDL番号:
MFCD10574689
PubChem Substance ID:
329770815
NACRES:
NA.77

品質水準

100

アッセイ

≥98% (HPLC)

形状

powder

色

white to tan

溶解性

DMSO: >10 mg/mL

オーガナイザー

Abbott

保管温度

room temp

SMILES string

COc1cc(NC(=O)c2ccc(o2)-c3ccc(Cl)cc3)cc(OC)c1

InChI

1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)

InChI key

VHKBTPQDHDSBSP-UHFFFAOYSA-N

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当該品目
5.08505A0862513030
A-803467 ≥98% (HPLC)

Sigma-Aldrich

A3109

A-803467

A-803467

Sigma-Aldrich

5.08505

A-803467

A-740003 ≥98% (HPLC)

Sigma-Aldrich

A0862

A-740003

PD 169316 A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM).

Sigma-Aldrich

513030

PD 169316

form

powder

form

solid

form

powder

form

solid

color

white to tan

color

white

color

white to light brown

color

orange-yellow

solubility

DMSO: >10 mg/mL

solubility

DMSO: 100 mM, ethanol: 25 mM

solubility

DMSO: 10 mg/mL, clear (warmed)

solubility

DMSO: 10 mg/mL

originator

Abbott

originator

-

originator

-

originator

-

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

詳細

A-803467 inhibits spontaneous and evoked action potentials in sensory neurons. It exhibits antinociceptive effects. A-803467 decreases the firing in spinal dorsal horn neurons in vivo.
The small molecule A-803467 is a potent and selective Nav1.8 sodium channel blocker. Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel that contributes to pain sensation by transmitting pain stimuli in peripheral sensory neurons; blockage of this channel by A-803467 reduces pain with varying effectiveness in a number of different models. A-803467 has been used to further understand the role of Nav1.8 in transmitting pain stimuli and also can be used as an analgesic.

生物化学的／生理学的作用

A-803467 blocks Nav1.8 in both half-maximal inactive and resting states with an IC50 of 8 nM and IC50 of 79 nM, respectively. A-803467 is over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7.

特徴および利点

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

Certificates of Analysis (COA)

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例

T1503
製品番号
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25G
容量／数量

その他の例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

入力例：1.000309185)

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Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich製品

  • もしTO09019TOなどのロット番号を見つけた場合は、最初の2文字を除いたロット番号09019TOを入力します。

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  • もしSTBB0728K9などの充てんコード付きロット番号を見つけた場合は、充てんコードのK9を除いたロット番号STBB0728を入力します。

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PF-05089771 ≥98% (HPLC)

Sigma-Aldrich

PZ0311

PF-05089771

Anti-SCN5A antibody produced in rabbit affinity isolated antibody

Sigma-Aldrich

SAB2107930

抗SCN5A抗体 ウサギ宿主抗体

Aconitine ≥95% (HPLC), crystalline

Sigma-Aldrich

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アコニチン

DNQX ≥98% (TLC)

Sigma-Aldrich

D0540

DNQX

The Inhibitor Index: A Desk Reference on Enzyme Inhibitors, Receptor Antagonists, Drugs, Toxins, Poisons, Biologics, and Therapeutic Leads (2017)
Anthony M Rush et al.
Molecular interventions, 7(4), 192-195 (2007-09-11)
Voltage-gated sodium channels in nociceptive neurons are attractive targets for novel pain therapeutics. Although drugs that target voltage-gated sodium channels have proven value as pain therapeutics, the drugs that are currently available are non-specific sodium channel inhibitors, which limit their
Peripheral Receptor Targets for Analgesia: Novel Approaches to Pain Management (2009)
K Bekő et al.
Journal of thrombosis and haemostasis : JTH, 15(6), 1223-1235 (2017-03-28)
Essentials The role of platelet P2Y Background P2Y
Mihai Moldovan et al.
Neurobiology of aging, 39, 128-139 (2016-03-01)
Accumulating myelin abnormalities and conduction slowing occur in peripheral nerves during aging. In mice deficient of myelin protein P0, severe peripheral nervous system myelin damage is associated with ectopic expression of Nav1.8 voltage-gated Na(+) channels on motor axons aggravating the
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資料

Sodium Channels

Voltage-gated sodium channels are present in most excitable cell membranes and play an important role in generating action potentials.

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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