Merck
All Photos(4)

A8674

Sigma-Aldrich

アンチマイシンA 放線菌由来

CAS Number:
MDL番号:
PubChem Substance ID:
NACRES:
NA.77

形状

powder

品質水準

抗生物質活性スペクトル

fungi

作用機序

enzyme | inhibits

保管温度

−20°C

SMILES string

[H]C(=O)Nc1cccc(C(=O)N[C@H]2[C@@H](C)OC(=O)C(CCCCCC)[C@@H](OC(=O)CC(C)C)[C@H](C)OC2=O)c1O

InChI

1S/C28H40N2O9/c1-6-7-8-9-11-20-25(39-22(32)14-16(2)3)18(5)38-28(36)23(17(4)37-27(20)35)30-26(34)19-12-10-13-21(24(19)33)29-15-31/h10,12-13,15-18,20,23,25,33H,6-9,11,14H2,1-5H3,(H,29,31)(H,30,34)/t17-,18+,20?,23+,25+/m1/s1

InChI key

UIFFUZWRFRDZJC-RBVQMQRASA-N

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1 of 4

This Item
M4287M6891H3274
form

powder

form

powder

form

-

form

powder

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

200

antibiotic activity spectrum

fungi

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

neoplastics

antibiotic activity spectrum

fungi

mode of action

enzyme | inhibits

mode of action

DNA synthesis | interferes

mode of action

DNA synthesis | interferes

mode of action

protein synthesis | interferes

詳細

Streptomyces(ストレプトミセス属)種が産生したアンチマイシン。 これは、ミトコンドリア電子伝達鎖複合体IIIを阻害し、活性酸素種(ROS)産生を起こしやすく、ミトコンドリアの脱分極を損ないます。これは、一酸化窒素媒介アポトーシスを阻害し、シトクロムC放出を調節します。これは、肺がん細胞における腫瘍形成を抑えるため、治療薬になる可能性があります。
化学構造:ペプチド

アプリケーション

Streptomyces sp.(放線菌)由来のアンチマイシンAは、以下の目的で使用されています:
  • ニューロン培養における呼吸鎖阻害剤として
  • Trypanosoma brucei細胞における細胞内小器官ATP産生アッセイに
  • 甲状腺乳頭癌(PTC)細胞株の呼吸アッセイ
アンチマイシンAは、慢性閉塞性肺疾患患者の骨格筋から単離されたミトコンドリアにおける活性酸素種産生の特異的部位を研究するため、および運動により誘発される局所酸化ストレスとの関係を研究するために使用されています。

生物化学的/生理学的作用

複合体Ⅲの電子伝達を阻害するインヒビタ-です。アポト-シスを誘導します。

品質

アンチマイシンの混合物

ピクトグラム

Skull and crossbonesEnvironment

シグナルワード

Danger

危険有害性情報

危険有害性の分類

Acute Tox. 2 Oral - Aquatic Acute 1

保管分類コード

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

個人用保護具 (PPE)

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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