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A8851

Sigma-Aldrich

アピシジン

≥98% (HPLC), from microbial

Synonym(s):
シクロ[(2S)-2-アミノ-8-オキソデカノイル-1-メトキシ-L-トリプトフィル-L-イソロイシル-(2R)-2-ピペリジンカルボニル]
Empirical Formula (Hill Notation):
C34H49N5O6
CAS Number:
Molecular Weight:
623.78
MDL番号:
PubChem Substance ID:
NACRES:
NA.77

由来生物

microbial

品質水準

無菌性

non-sterile

アッセイ

≥98% (HPLC)

形状

solid

溶解性

DMSO: ~1 mg/mL

抗生物質活性スペクトル

parasites

作用機序

enzyme | inhibits

輸送温度

wet ice

保管温度

−20°C

SMILES string

[H][C@]12CCCCN1C(=O)[C@@H](NC(=O)[C@H](Cc3cn(OC)c4ccccc34)NC(=O)[C@H](CCCCCC(=O)CC)NC2=O)C(C)CC

InChI

1S/C34H49N5O6/c1-5-22(3)30-34(44)38-19-13-12-18-29(38)33(43)35-26(16-9-7-8-14-24(40)6-2)31(41)36-27(32(42)37-30)20-23-21-39(45-4)28-17-11-10-15-25(23)28/h10-11,15,17,21-22,26-27,29-30H,5-9,12-14,16,18-20H2,1-4H3,(H,35,43)(H,36,41)(H,37,42)/t22?,26-,27-,29+,30?/m0/s1

InChI key

JWOGUUIOCYMBPV-PYAAAQPJSA-N

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This Item
SMB00702107981040683
Apicidin ≥98% (HPLC), from microbial

Sigma-Aldrich

A8851

アピシジン

Apigenin ≥97% (TLC), from citrus

Sigma-Aldrich

SMB00702

アピゲニン

Apigenin ≥95.0% (HPLC)

Sigma-Aldrich

10798

アピゲニン

Apigenin United States Pharmacopeia (USP) Reference Standard

USP

1040683

アピゲニン

assay

≥98% (HPLC)

assay

≥97% (TLC)

assay

≥95.0% (HPLC)

assay

-

form

solid

form

powder

form

-

form

-

solubility

DMSO: ~1 mg/mL

solubility

DMSO: 27 mg/mL, 1 M KOH: 50 mg/mL

solubility

-

solubility

-

shipped in

wet ice

shipped in

-

shipped in

-

shipped in

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

-

詳細

Apicidin is a cyclic tetrapeptide fungal metabolite.

アプリケーション

Apicidin has been used as a histone deacetylase 2 (HDAC2) inhibitor to study its effects on 5-lipoxygenase (5-LO) mRNA expression in cell lines of Mono Mac6. It has also been used to study the effects of toll-like receptor 8 (TLR-8) stimulation and histone modification on the expression of an activator protein 1 [AP-1] family member(Fra-2) and tissue inhibitor of metalloproteinases 1 (TIMP-1) in monocytes.

生物化学的/生理学的作用

Apicidin is a potent inhibitor of histone deacetylase (HDAC). It particularlyinhibits histone deacetylase 1 and 3 (HDAC1 and HDAC3). Apicidin exhibits anti-protozoal activity against apicomplexan metabolite produced by parasites. It also possesses anti-proliferative activity against several cancer cell lines. Apicidin shows anti-cancer activity against human acute promyelocytic leukemia cell.

特徴および利点

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

個人用保護具 (PPE)

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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