AV100751

Sigma-Aldrich

Anti-ETS2 antibody produced in rabbit

affinity isolated antibody

別名:
Anti-v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
NACRES:
NA.41

由来生物

rabbit

品質水準

100

抗体製品の状態

affinity isolated antibody

antibody product type

primary antibodies

クローン

polyclonal

形態

buffered aqueous solution

分子量

53 kDa

species reactivity

mouse, human, guinea pig, rat, dog

濃度

0.5 mg - 1 mg/mL

アプリケーション

western blot: suitable

結合体

unconjugated

NCBIアクセッション番号

UniProtアクセッション番号

出荷済み

wet ice

保管温度

−20°C

Gene Information

human ... ETS2(2114)

詳細

ETS2 belongs to the Ets family of transcription factors that are crucial mediators of extracellular matrix remodeling. The Ets family members are regulators of bone and cartilage development.

免疫原

The immunogen for anti-ETS2 antibody: synthetic peptide derected towards the middle region of human ETS2

アプリケーション

Anti-ETS2 antibody produced in rabbit is suitable for western blotting at a concentration of 0.25 μg/ml.

生物化学的/生理学的作用

ETS family members have binding sites for AP-1 and MAPK proteins. ETS2 significantly regulates the skeletal development and differentiation of osteoblasts. Decreased expression of ETS2 results in skeletal abnormalities similar to those observed in humans with Down′s syndrome. Studies show that ETS2 promotes angiogenesis breast cancer progression.

シーケンス

Synthetic peptide located within the following region: FESFEDDCSQSLCLNKPTMSFKDYIQERSDPVEQGKPVIPAAVLAGFTGS

物理的形状

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

ドイツ水質汚染分類

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

試験成績書(COA)
原産地証明書(COO)
J S Yordy et al.
Oncogene, 19(55), 6503-6513 (2001-02-15)
Cellular responses to environmental stimuli are controlled by a series of signaling cascades that transduce extracellular signals from ligand-activated cell surface receptors to the nucleus. Although most pathways were initially thought to be linear, it has become apparent that there...
A Raouf et al.
Oncogene, 19(55), 6455-6463 (2001-02-15)
Bone formation in vivo is a complex phenomenon whereby recruitment and replication of mesenchymal precursors of osteoblasts, differentiation into preosteoblasts, osteoblasts, and mature osteoblasts ultimately result in the accumulation and mineralization of the extracellular matrix. MC3T3-E1, a clonal osteoblastic cell...
M Trojanowska
Oncogene, 19(55), 6464-6471 (2001-02-15)
Ets factors are critical mediators of extracellular matrix (ECM) remodelling. As the spectrum of Ets-regulated target genes widens, so does their role in various pathological and physiological processes. Regulation of matrix degrading proteases by Ets factors in tumor invasion and...
Julie A Wallace et al.
PloS one, 8(8), e71533-e71533 (2013-08-27)
Tumor fibroblasts are active partners in tumor progression, but the genes and pathways that mediate this collaboration are ill-defined. Previous work demonstrates that Ets2 function in stromal cells significantly contributes to breast tumor progression. Conditional mouse models were used to...

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