AV48225

Sigma-Aldrich

Anti-VIM (AB1) antibody produced in rabbit

affinity isolated antibody

別名:
抗ビメンチン抗体

由来生物

rabbit

抗体製品の状態

affinity isolated antibody

antibody product type

primary antibodies

クローン

polyclonal

形態

lyophilized powder

分子量

54 kDa

species reactivity

human, mouse, rat, bovine, rabbit, guinea pig, sheep, horse

濃度

0.5 mg - 1 mg/mL

アプリケーション

western blot: suitable

結合体

unconjugated

NCBIアクセッション番号

UniProtアクセッション番号

保管温度

−20°C

Gene Information

human ... VIM(7431)

詳細

Vimentin is a type III intermediary filament protein that is present in mesenchymal tissues. Vimentins regulate several cellular functions such as response to mechanical stress, cell shape, and cell movement. These proteins may also be involved in the pathogenesis of tissue fibrosis . Anti-VIM (AB1) antibody is specific for VIM in humans, bovines, rats, mice and chickens.

免疫原

The immunogen for anti-VIM antibody: synthetic peptide derected towards the N terminal of human VIM

アプリケーション

Anti-VIM (AB1) antibody is suitable for use in western blot.

シーケンス

Synthetic peptide located within the following region: LNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRR

物理的形状

Lyophilized from PBS buffer with 2% sucrose

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

試験成績書(COA)

原産地証明書(COO)

Toshifumi Murai et al.
Journal of surgical oncology, 109(7), 684-689 (2014-01-24)
Epithelial-to-mesenchymal transition (EMT) is considered to play an important role in cancer invasion and metastasis. The mRNA levels of an epithelial marker (E-cadherin), mesenchymal marker (vimentin), and Zeb-1 were measured in 11 gastric cancer cell lines. Functional analysis was performed...
Azariyas A Challa et al.
Molecular and cellular biology, 31(18), 3773-3789 (2011-07-13)
The stem-loop in the 5' untranslated region (UTR) of collagen α1(I) and α2(I) mRNAs (5'SL) is the key element regulating their stability and translation. Stabilization of collagen mRNAs is the predominant mechanism for high collagen expression in fibrosis. LARP6 binds...
Jun Won Park et al.
Molecular cancer research : MCR, 12(8), 1088-1099 (2014-05-03)
Loss of E-cadherin (CDH1), Smad4, and p53 has been shown to play an integral role in gastric, intestinal, and breast cancer formation. Compound conditional knockout mice for Smad4, p53, and E-cadherin were generated to define and compare the roles of...
Alexandra von Baer et al.
Pathology, research and practice, 210(10), 698-703 (2014-07-01)
Extraskeletal osteosarcoma is a rare neoplasia within the broad differential diagnostic spectrum of calcifying intramuscular lesions. We present a case of a slowly increasing mass within the left vastus lateralis muscle. At first presentation the patient showed a partially calcified...
Xingchen Zhou et al.
PloS one, 9(5), e96718-e96718 (2014-05-13)
Epidermal growth factor receptor (EGFR) overexpression and activation result in increased proliferation and migration of solid tumors including ovarian cancer. In recent years, mounting evidence indicates that EGFR is a direct and functional target of miR-7. In this study, we...

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