QPRT (quinolinate phosphoribosyltransferase) is an essential enzyme of quinolinate catabolism, and has a molecular weight of 34kDa. It is found in both the cytoplasm and nucleus, and is expressed in central nervous system cells, platelets, erythrocytes and liver. It belongs to the type II phosphoribosyltransferase family. Its active site is situated at an α/β open sandwich region.
Recombinant quinolinate phosphoribosyltransferase
Immunogen Sequence: GI # 45269149, sequence 123-237
Anti-QPRT antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Mammalian quinolinate phosphoribosyltransferase (QPRTase) is a key enzyme in catabolism of quinolinate. It is an intermediate in the tryptophan-nicotinamide adenine dinucleotide (NAD) pathway. Quinolinate acts as a potent endogenous exitotoxin to neurons and an elevation in its levels in the brain is linked to the pathogenesis of neurodegenerative disorders. QPRT acts at the junction of two different pathways, de novo NAD+ biosynthesis and the kynurenine pathway of tryptophan degradation. It is an important enzyme in terms of its biological impact and its potential as a therapeutic target.
Solution in phosphate buffered saline containing 0.02% sodium azide.
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