GW22306F

Sigma-Aldrich

Anti-QPRT antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

NACRES:
NA.41

由来生物

chicken

品質水準

200

抗体製品の状態

affinity isolated antibody

antibody product type

primary antibodies

クローン

polyclonal

形態

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-22306F

アプリケーション

western blot: suitable

結合体

unconjugated

NCBIアクセッション番号

UniProtアクセッション番号

出荷済み

wet ice

保管温度

−20°C

Gene Information

human ... QPRT(23475)

詳細

QPRT (quinolinate phosphoribosyltransferase) is an essential enzyme of quinolinate catabolism, and has a molecular weight of 34kDa. It is found in both the cytoplasm and nucleus, and is expressed in central nervous system cells, platelets, erythrocytes and liver. It belongs to the type II phosphoribosyltransferase family. Its active site is situated at an α/β open sandwich region.

免疫原

Recombinant quinolinate phosphoribosyltransferase
Immunogen Sequence: GI # 45269149, sequence 123-237

アプリケーション

Anti-QPRT antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

生物化学的/生理学的作用

Mammalian quinolinate phosphoribosyltransferase (QPRTase) is a key enzyme in catabolism of quinolinate. It is an intermediate in the tryptophan-nicotinamide adenine dinucleotide (NAD) pathway. Quinolinate acts as a potent endogenous exitotoxin to neurons and an elevation in its levels in the brain is linked to the pathogenesis of neurodegenerative disorders. QPRT acts at the junction of two different pathways, de novo NAD+ biosynthesis and the kynurenine pathway of tryptophan degradation. It is an important enzyme in terms of its biological impact and its potential as a therapeutic target.

物理的形状

Solution in phosphate buffered saline containing 0.02% sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

個人用保護具 (PPE)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

RIDADR

NONH for all modes of transport

ドイツ水質汚染分類

WGK 2

引火点(°F)

Not applicable

引火点(℃)

Not applicable

試験成績書(COA)
原産地証明書(COO)
Shuja S Malik et al.
Proteins, 82(3), 405-414 (2013-09-17)
Quinolinic acid (QA), a biologically potent but neurodestructive metabolite is catabolized by quinolinic acid phosphoribosyltransferase (QPRT) in the first step of the de novo NAD(+) biosynthesis pathway. This puts QPRT at the junction of two different pathways, that is, de...
S I Fukuoka et al.
Biochimica et biophysica acta, 1395(2), 192-201 (1998-02-25)
Mammalian quinolinate phosphoribosyltransferase (QPRTase) (EC 2.4.2.19) is a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide (NAD) pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain...
Huanting Liu et al.
Journal of molecular biology, 373(3), 755-763 (2007-09-18)
Human quinolinate phosphoribosyltransferase (EC 2.4.2.19) (hQPRTase) is a member of the type II phosphoribosyltransferase family involved in the catabolism of quinolinic acid (QA). It catalyses the formation of nicotinic acid mononucleotide from quinolinic acid, which involves a phosphoribosyl transfer reaction...

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