Merck
  • K3644
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K3644

Sigma-Aldrich

K 858

≥98% (HPLC)

Synonym(s):
K858, N-(4-アセチル-4,5-ジヒドロ-5-メチル-5-フェニル-1,3,4-チアジアゾール-2-イル)アセトアミド
Empirical Formula (Hill Notation):
C13H15N3O2S
CAS Number:
Molecular Weight:
277.34
MDL番号:
PubChem Substance ID:
NACRES:
NA.77

品質水準

アッセイ

≥98% (HPLC)

形状

powder

white to off-white

溶解性

DMSO: ≥20 mg/mL

保管温度

2-8°C

SMILES string

CC(=O)NC1=NN(C(C)=O)C(C)(S1)c2ccccc2

InChI

1S/C13H15N3O2S/c1-9(17)14-12-15-16(10(2)18)13(3,19-12)11-7-5-4-6-8-11/h4-8H,1-3H3,(H,14,15,17)

InChI key

JEFVYQYZCAVNTP-UHFFFAOYSA-N

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K 858 ≥98% (HPLC)

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assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

-

form

powder

form

powder

color

white to off-white

color

white to beige

color

white to beige

color

white to beige

solubility

DMSO: ≥20 mg/mL

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

生物化学的/生理学的作用

Eg5は、双極紡錘体の形成に関与する重要なタンパク質です。K858は、分裂キネシンEg5に選択的なATP非競合性のインヒビターです。この化合物は、HCT116細胞において分裂停止、カスパーゼ-3活性化、細胞増殖の阻害を引き起こします。

ピクトグラム

Exclamation mark

シグナルワード

Warning

危険有害性情報

危険有害性の分類

Acute Tox. 4 Oral

保管分類コード

11 - Combustible Solids

WGK

WGK 1

引火点(°F)

Not applicable

引火点(℃)

Not applicable


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