L1167

ラタノプロスト

≥98% (HPLC)

• Synonym(s): イソプロピル(5Z,9α,11α,15R)-9,11,15-トリヒドロキシ-17-フェニル-18,19,20-トリノル-プロスト-5-エン-1-オエート, キサラタン
• Empirical Formula (Hill Notation): C₂₆H₄₀O₅
• CAS Number: 130209-82-4
• Molecular Weight: 432.59
• MDL番号: MFCD00216074
• PubChem Substance ID: 24724523
• NACRES: NA.77

Properties

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: oil
• 色: colorless to yellow
• 溶解性: DMSO: freely soluble; methanol: soluble
• オーガナイザー: Johnson & Johnson
• 輸送温度: wet ice
• 保管温度: −20°C
• SMILES string: CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc2ccccc2
• InChI: 1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3-/t21-,22+,23+,24-,25+/m0/s1
• InChI key: GGXICVAJURFBLW-CEYXHVGTSA-N
• Gene Information: human ... PTGFR(5737)

Description

アプリケーション

Latanoprost has been used:

• in the preparation of thermo-sensitive hydrogel consisting of curcumin-loaded nanoparticles (CUR-NPs) to determine its therapeutic effects on human trabecular meshwork (TM) cells under oxidative stress.
• as an ester pro-drug to study its effects on the murine ocular surface in mice.
• in the preparation of thermo-sensitive hydrogel to study its effects on controlling ocular hypertension.

生物化学的／生理学的作用

Latanoprost is a potent, selective prostaglandin F2α analog receptor agonist. It is hydrolyzed by esterases into its biologically active form latanoprost acid in the cornea. Latanoprostplays a role in reducing the intraocular pressure (IOP) due to which it has therapeutic effects in treating glaucoma.

特徴および利点

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type N95 (US)