Merck
All Photos(3)

M9281

Sigma-Aldrich

3-メチルアデニン

autophagy inhibitor

Synonym(s):
3-MA, 6-アミノ-3-メチルプリン
Empirical Formula (Hill Notation):
C6H7N5
CAS Number:
Molecular Weight:
149.15
Beilstein:
146087
EC 番号:
MDL番号:
PubChem Substance ID:
NACRES:
NA.51

品質水準

300

アッセイ

≥99% (HPLC)

形態

powder

mp

~300 °C (dec.) (lit.)

溶解性

DMF: 9.80-10.20 mg/mL, clear, colorless to light yellow

SMILES string

Cn1cnc(N)c2ncnc12

InChI

1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3

InChI key

FSASIHFSFGAIJM-UHFFFAOYSA-N

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アプリケーション

発がんにおける核酸のメチル化検出のスタンダード。
3-Methyladenine (3-MA) is used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concentration of 5 mM.
3-Methyladenine has been used as an autophagy inhibitor:
  • to determine the expressions of autophagy-related genes (Beclin 1, light chain 3 (LC3) and p62) using the transfected human bone marrow mesenchymal stem cells (BM-MSCs)
  • with cisplatin to study the inhibition of autophagy influenced cisplatin-induced apoptosis in A2780cp cells
  • to study the interplay between colistin-induced autophagy and apoptosis

包装

100, 500 mg in poly bottle

生物化学的/生理学的作用

3-Methyladenine (3-MA) is used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III phosphatidylinositol 3-kinases (PI-3K).

調製ノート

本製品はDMFに溶解します(10 mg/mL;穏やかに加熱しなければならない場合があります)。 また、加熱すれば水、95%エタノール、または1 N NaOHに30 mg/mLの濃度で溶解しますが、冷却すると溶液から析出します。 3-MAをDMSOに溶解し、100 mMの溶液を調製することができます。

保管分類コード

13 - Non Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

Certificate of Analysis

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Certificate of Origin

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