Merck

P4668

Sigma-Aldrich

プラジクアンテル

anthelminic, neurogenic

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別名:
2-(シクロヘキシルカルボニル)-1,2,3,6,7-11b-ヘキサヒドロ-4H-ピラジノ[2,1-aイソキノリン-4-オン
Empirical Formula (Hill Notation):
C19H24N2O2
CAS番号:
分子量:
312.41
Beilstein:
761557
EC Number:
MDL番号:
PubChem Substance ID:
NACRES:
NA.85

形状

powder or crystals

抗生物質活性スペクトル

parasites

作用機序

cell membrane | interferes

保管温度

−20°C

SMILES string

O=C1CN(CC2N1CCc3ccccc23)C(=O)C4CCCCC4

InChI

1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2

InChI key

FSVJFNAIGNNGKK-UHFFFAOYSA-N

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関連するカテゴリー

アプリケーション

Praziquantel is a potent anthelmintic used against schistosome and many cestode infestations. It is used to study voltage-gated Ca2+ channels and is a potential small molecule neurogenic.

生物化学的/生理学的作用

Praziquantel increases the permeability of the tegmentum to Ca2+ which results in the contraction of schistosomes and death. Praziquantel causes vacuolization and disintegration of the schistosome tegument. It is more effective on adult worms than young worms. It inhibits glucose uptake, which lowers glycogen levels and stimulates lactate release. Praziquantel is a potent anthelmintic against parasitic flatworms (flukes and tapeworms). Recent studies have indicated that praziquantel binds to a varient of the β-subunit of the voltage gated Ca2+ channel and to actin, which is a component of some Ca2+ channels.

その他情報

1g,5g,25g
Keep container tightly closed in a dry and well-ventilated place.

危険有害性情報

注意書き

危険有害性の分類

Aquatic Chronic 3

保管分類コード

11 - Combustible Solids

WGK

WGK 1

個人用保護具 (PPE)

Eyeshields, Gloves, type N95 (US)


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T1503
製品番号
-
25G
容量/数量

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705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

以下のように入力してください 1.000309185)

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Pyrantel pamoate United States Pharmacopeia (USP) Reference Standard

USP

1584003

ピランテルパモ酸塩

Oxantel pamoate analytical standard

Supelco

O4755

Oxantel pamoate

Pyrantel Pamoate Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR2080

ピランテルパモ酸塩

Pyrantel pamoate VETRANAL®, analytical standard

Supelco

46702

ピランテルパモ酸塩

Ivermectin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1380

イベルメクチン

Ivermectin

Sigma-Aldrich

I8898

イベルメクチン

Albendazole analytical standard, ≥98%

Supelco

A4673

アルベンダゾール

Fenbendazole ≥98%

Sigma-Aldrich

F5396

フェンベンダゾール

Fiona Ronketti et al.
Bioorganic & medicinal chemistry letters, 17(15), 4154-4157 (2007-06-09)
Several analogues of the potent anthelmintic praziquantel were prepared with variation in the aromatic ring. The biological activity of these analogues was evaluated and compared against known analogues. Amination of the ring was tolerated while other variations were not. These
R J Martin et al.
Parasitology, 114 Suppl, S111-S124 (1997-01-01)
This paper reviews sites of action of anthelmintic drugs including: (1) levamisole and pyrantel, which act as agonists at nicotinic acetylcholine receptors of nematodes; (2) the avermectins, which potentiate or gate the opening of glutamategated chloride channels found only in
Yuxiang Dong et al.
Bioorganic & medicinal chemistry letters, 20(8), 2481-2484 (2010-03-23)
Six amide and four urea derivatives of praziquantel were synthesized and tested for antischistosomal activity against juvenile and adults stages of Schistosoma mansoni in infected mice. Only one of these had significant activity against adult worms, but, unlike praziquantel, six
Dan Zhang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(44), 15983-15995 (2011-11-04)
There is intense interest in developing methods to regulate proliferation and differentiation of stem cells into neuronal fates for the purposes of regenerative medicine. One way to do this is through in vivo pharmacological engineering using small molecules. However, a
F de Marval et al.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 18(3) (2013-01-29)
Following a first clinical case of infection by Diphyllobothrium dendriticum in Switzerland in 2006, we report a second case in the country. The species was identified by molecular methods. In the Swiss, French and Italian subalpine regions, human diphyllobothriasis has

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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