PLA0199

Sigma-Aldrich

Rabbit anti-Vimentin Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

別名:
CTRCT30, HEL113, epididymis luminal protein 113
NACRES:
NA.41

由来生物

rabbit

品質水準

100

抗体製品の状態

affinity purified immunoglobulin

antibody product type

primary antibodies

グレード

Powered by Bethyl Laboratories, Inc.

species reactivity

mouse, human

アプリケーション

immunohistochemistry: 1:200-1:1,000
western blot: 1:2,000- 1:10,000

アクセッション番号

NP_003371.2

出荷済み

wet ice

保管温度

2-8°C

Gene Information

rabbit ... Vimentin(7431)

詳細

Vimentin is a specific type III intermediate filament (IF) protein. It is abundantly expressed in mesenchymal cells. The gene encoding this protein is localized on human chromosome 10p13.

免疫原

The epitope recognized by PLA0199 maps to a region between residue 416 and 466 of human vimentin using the numbering given in entry NP_003371.2 (GeneID 7431).

生物化学的/生理学的作用

Vimentin helps to preserve the structure of cell and stability of tissue in mesenchymal cells. It is involved in tumorigenesis, EMT (epithelial mesenchymal transition) and the metastatic spread of cancer. It also controls infectious internalization of human papillomavirus 16 pseudovirions.

物理的形状

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

その他情報

Vimentin is an intermediate filament expressed mainly in mesenchymal tissue and in primitive (undifferentiated) non-mesenchymal cells. It is a Class III cytoplasmic filament that forms a dense cytoskeletal network that extends from the nucleus to the plasma membrane. Vimentin reorganization during mitosis is likely regulated via its multiple phosphorylation sites. Vimentin expression is also found in mesoderm derived epithelia. Immunohistochemistry (IHC) with anti-vimentin antibodies is often used to identify neoplasms of mesenchymal or mesodermal origin.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

storage_class_code

12 - Non Combustible Liquids

引火点(°F)

Not applicable

引火点(℃)

Not applicable

試験成績書(COA)

原産地証明書(COO)

Vimentin modulates infectious internalisation of HPV16 pseudovirions
Schafer G, et al.
Journal of Virology, JVI-00307 (2017)
null
Mohammad Mehedi Hasan et al.
International journal of molecular sciences, 21(15) (2020-08-01)
While follicular fluid (FF) is well known to provide an optimal environment for oogenesis, its functional roles following its release into the oviduct during ovulation are currently elusive. We hypothesized that FF and FF-derived extracellular vesicles (EVs) may be conveyors...
Viscoelastic properties of vimentin compared with other filamentous biopolymer networks.
Janmey PA, et al.
The Journal of Cell Biology, 113(1), 155-160 (1991)
Vimentin is a potential prognostic factor for tongue squamous cell carcinoma among five epithelial?mesenchymal transition-related proteins.
Liu P F, et al.
PLoS ONE, 12(6), e0178581-e0178581 (2017)

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

テクニカルサービス連絡先