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S0130

Sigma-Aldrich

ストレプトゾシン

≥75% α-anomer basis, ≥98% (HPLC), powder

別名:
N-(メチルニトロソカルバモイル)-α-D-グルコサミン, ストレプトゾトシン
Empirical Formula (Hill Notation):
C8H15N3O7
CAS番号:
分子量:
265.22
Beilstein:
2060675
EC 番号:
MDL番号:
PubChem Substance ID:
NACRES:
NA.77

品質水準

200

アッセイ

≥75% α-anomer basis
≥98% (HPLC)

形態

powder

white to light yellow

mp

121 °C (dec.) (lit.)

作用機序

DNA synthesis | interferes

抗生物質活性スペクトル

neoplastics

オーガナイザー

Pfizer

保管温度

−20°C

SMILES string

CN(N=O)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O

InChI

1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1

InChI key

ZSJLQEPLLKMAKR-GKHCUFPYSA-N

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関連するカテゴリー

詳細

ストレプトゾシンまたはストレプトゾトシンは、Streptomyces achromogenesから得られます。グルコサミン-ニトロソウレアであるストレプトゾトシンは、GLUT2 グルコース輸送タンパク質を介すことでしか細胞内に入ることができない、DNA アルキル化試薬です。糖尿病誘起物質であるストレプトゾシンは、特に膵島インスリン産生β細胞に対して毒性を示します。GLUT2 陽性の神経内分泌腫瘍細胞に毒性を示します。

アプリケーション

ストレプトゾシンまたはストレプトゾトシンは、医学研究において、1 型糖尿病の誘導に使用されます。

包装

50, 100, 500 mg in glass bottle
1, 5 g in glass bottle

生物化学的/生理学的作用

膵島において一酸化窒素ドナーとして働く N-ニトロソ含有化合物は、インスリン産生細胞の細胞死を誘導し、糖尿病の動物モデルを提供します。クロモソーム破壊を誘導する強力な DNA メチル化試薬です。 GLUT2 グルコーストランスポーターを発現する、神経内分泌腫瘍細胞株に対して毒性を示します。
本化合物は、臨床において、膵臓β細胞癌の治療に使用されます。

特徴および利点

この化合物は、Pfizerによって開発されました。他の医薬由来化合物や承認済み医薬品/医薬品候補のリストを見るには、こちらをクリックしてください

その他情報

アノマー混合物

ピクトグラム

FlameHealth hazard

シグナルワード

Warning

危険有害性情報

危険有害性の分類

Carc. 2 - Flam. Sol. 2 - Muta. 2

保管分類コード

4.1B - Flammable solid hazardous materials

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

個人用保護具 (PPE)

Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

試験成績書(COA)

原産地証明書(COO)

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How should I store Product S0130, Streptozocin, upon receipt?

    Streptozocin should be stored at -20 degrees C with desiccation.  The desiccant is to prevent moisture uptake which can shorten shelf-life.

  3. How do I store solutions of Product S0130, Streptozocin?

    Aqueous solutions rapidly undergo mutarotation to an equilibrium mixture of alpha- and beta-anomers.  Maximum solution stability is at pH 4, with stability decreasing rapidly at higher or lower pH. Freshly prepared solutions are clear and have a light straw color. On standing, they take on a yellow to brown color and effervesce, indicating decomposition.   Solutions should be prepared just before use, since the product is unstable.

  4. What is the half-life of Product S0130, Streptozocin?

    Streptozocin has a reported half life of 15 to 30 minutes.

  5. How can I make a solution of Product S0130, Streptozocin?

    This product dissolves in water at 50 mg/mL to give a light yellow solution, from clear to slightly hazy. We recommend using a 20 mM citrate buffer at pH 4.5 for best solution stability.

  6. Can Product S0130, Streptozocin, be used to induce diabetes?  What concentration should be used?

    We do not test Streptozocin, Product No. S0130 for biological activity.  We recommend screening lots for biological activity.  An intravenous injection of streptozocin into rats at a dose of 65 mg/kg body weight to induce diabetes has been reported by Burcelin R. et al. in Biochem. J., 291, 109-113 (1993).

  7. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  8. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  9. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Cordyceps militaris Treatment Preserves Renal Function in Type 2 Diabetic Nephropathy Mice
Sung-Hsun Yu
PLoS ONE (2016)
Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans
Chinedum
Journal of diabetes and metabolic disorders, 12, 60-60 (2013)
Housekeeping proteins: How useful are they in skeletal muscle
diabetes studies and muscle hypertrophy models?
Marco
Analytical Biochemistry, 504, 38-40 (2016)
Navneet Kumar Dubey et al.
International journal of molecular sciences, 19(10) (2018-10-05)
Recent years have witnessed an increased prevalence of knee osteoarthritis (KOA) among diabetes mellitus (DM) patients-conditions which might share common risk factors such as obesity and advanced aging. Therefore, we conducted dry-to-wet lab research approaches to assess the correlation of
The Streptozotocin-Induced Diabetic Nude Mouse Model: Differences between Animals from Different Sources
Melanie L Graham
Comparative Medicine, 61(4), 356-360 (2011)

資料

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