SAB1300023

Sigma-Aldrich

Anti-TYRO10 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

別名:
Anti-Receptor-relate3, Anti-Tyrosine-protein kinase TYRO 10, Anti-Receptor protein-tyrosine kinase TKT, Anti-Discoidin domain receptor 2, Neurotrophic tyrosine kinase
NACRES:
NA.41

由来生物

rabbit

品質水準

100

抗体製品の状態

IgG fraction of antiserum

antibody product type

primary antibodies

クローン

polyclonal

形態

buffered aqueous solution

species reactivity

human

アプリケーション

indirect ELISA: 1:1000
western blot: 1:100-1:500

結合体

unconjugated

NCBIアクセッション番号

UniProtアクセッション番号

出荷済み

dry ice

保管温度

−20°C

Gene Information

human ... TYRO10(4921)

詳細

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane and cytoplasmic regions. There are several subclasses of RTKs and TYRO10 belongs to a novel subclass. The deduced amino acid sequence of TYRO10 has a unique extracellular region encompassing a factor VIII-like domain, not previously described for RTKs.

免疫原

TYRO10 (294-330)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from aa 304-320 of human TYRO10.

物理的形状

精製済みポリクローナル抗体のPBS溶液(0.09%(W/V)アジ化ナトリウム含有)

RIDADR

NONH for all modes of transport

ドイツ水質汚染分類

nwg

引火点(°F)

Not applicable

引火点(℃)

Not applicable

試験成績書(COA)
原産地証明書(COO)
Janet M C Ngu et al.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, 23(6), 335-343 (2014-07-26)
Tissue inhibitor of metalloproteinase-2 (TIMP-2) is an endogenous inhibitor of matrix metalloproteinases (MMPs) that attenuates maladaptive cardiac remodeling in ischemic heart failure. We examined the effects of TIMP-2 on human cardiac fibroblast activation and extracellular matrix (ECM) remodeling. Human cardiac...

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