SAB1300153

Sigma-Aldrich

Anti-RANBP2 (N-term) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

別名:
Nucleoporin Nup358, Nuclear pore complex protein Nup358, Anti-358 kDa nucleoporin, Anti-RanBP2, Anti-Ran-binding protein 2
NACRES:
NA.41

由来生物

rabbit

品質水準

100

抗体製品の状態

IgG fraction of antiserum

antibody product type

primary antibodies

クローン

polyclonal

形態

buffered aqueous solution

species reactivity

human

アプリケーション

immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000

結合体

unconjugated

NCBIアクセッション番号

UniProtアクセッション番号

出荷済み

dry ice

保管温度

−20°C

Gene Information

human ... RANBP2(5903)

詳細

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q.

免疫原

RANBP2 (NP_006258, 160-194)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human RANBP2.

物理的形状

精製済みポリクローナル抗体のPBS溶液(0.09%(W/V)アジ化ナトリウム含有)

storage_class_code

12 - Non Combustible Liquids

ドイツ水質汚染分類

nwg

引火点(°F)

Not applicable

引火点(℃)

Not applicable

試験成績書(COA)

原産地証明書(COO)

Hyunjung Choi et al.
Journal of dermatological science, 76(1), 60-66 (2014-08-19)
The interactions between human epidermal melanocytes and their cellular microenvironment are important in the regulation of human melanocyte functions or in their malignant transformation into melanoma. Although the basement membrane extracellular matrix (BM-ECM) is one of major melanocyte microenvironments, the...

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