SAB1300358

Sigma-Aldrich

Anti-MTMR2 (N-term) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

由来生物

rabbit

品質水準

100

抗体製品の状態

IgG fraction of antiserum

antibody product type

primary antibodies

クローン

polyclonal

形態

buffered aqueous solution

species reactivity

human

アプリケーション

indirect ELISA: 1:1000
western blot: 1:100-1:500

結合体

unconjugated

NCBIアクセッション番号

UniProtアクセッション番号

出荷済み

dry ice

保管温度

−20°C

Gene Information

human ... MTMR2(8898)

詳細

The MTMR2 gene encodes a member of the myotubularin family, characterized by the presence of a phosphatase domain. Mutations in the myotubularin gene (MTM) cause X-linked myotubular myopathy. Northern blot analysis reveals that the 4-kb MTMR2 mRNA is expressed ubiquitously. The mouse Mtmr2 gene encodes a 643-amino acid protein that shares 97% sequence identity with the human protein. Mouse Mtmr2 dephosphorylates phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI3,5P2), most effectively at neutral pH. This is distinct from the activity of myotubularin, which only acts on PI3P. Analysis of MTMR2 mutations associated with Charcot-Marie-Tooth disease type 4B (CMT4B1) show markedly diminished phosphatase activity, suggesting that this activity is crucial for the proper functioning of peripheral nerves. MTMR2 mutations may lead to malfunction of neural membrane recycling, membrane trafficking, and endo- and exocytic processes. Loss-of-function mutations in MTMR2 are associated with the CMT4B phenotype. MTMR2 interacts with MTMR5, and mutations in the coiled-coil domain of either MTMR2 or MTMR5 abolish this interaction. Through this interaction, MTMR5 promotes enzymatic activity of MTMR2 and prescribe subcellular localization.

免疫原

MTMR2 (NP_003903, 7-35)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MTMR2.

物理的形状

精製済みポリクローナル抗体のPBS溶液(0.09%(W/V)アジ化ナトリウム含有)

RIDADR

NONH for all modes of transport

ドイツ水質汚染分類

nwg

引火点(°F)

Not applicable

引火点(℃)

Not applicable

試験成績書(COA)
原産地証明書(COO)

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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