SAB1403101

Sigma-Aldrich

Monoclonal Anti-ADAM30 antibody produced in mouse

clone 3E5, purified immunoglobulin, buffered aqueous solution

別名:
svph4
NACRES:
NA.41

品質水準

100

由来生物

mouse

抗体製品の状態

purified immunoglobulin

antibody product type

primary antibodies

クローン

3E5, monoclonal

形態

buffered aqueous solution

分子量

antigen ~37.11 kDa

species reactivity

human

アプリケーション

indirect ELISA: suitable

アイソタイプ

IgG2bκ

結合体

unconjugated

NCBIアクセッション番号

UniProtアクセッション番号

出荷済み

dry ice

保管温度

−20°C

Gene Information

human ... ADAM30(11085)

詳細

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is testis-specific and contains a polymorphic region, resulting in isoforms with varying numbers of C-terminal repeats. (provided by RefSeq)

免疫原

ADAM30 (NP_068566, 199 a.a. ~ 298 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
YKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQ

生物化学的/生理学的作用

Low levels of ADAM metallopeptidase domain 30 (ADAM30) has been linked to increased amyloid-β production and development of Alzheimer′s disease.

物理的形状

無色透明のPBS溶液、pH 7.4

RIDADR

NONH for all modes of transport

ドイツ水質汚染分類

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

試験成績書(COA)
原産地証明書(COO)
The ADAMs family of metalloproteases: multidomain proteins with multiple functions.
Darren F Seals et al.
Genes & development, 17(1), 7-30 (2003-01-07)
Florent Letronne et al.
EBioMedicine, 9, 278-292 (2016-06-23)
Although several ADAMs (A disintegrin-like and metalloproteases) have been shown to contribute to the amyloid precursor protein (APP) metabolism, the full spectrum of metalloproteases involved in this metabolism remains to be established. Transcriptomic analyses centred on metalloprotease genes unraveled a...
D P Cerretti et al.
Biochemical and biophysical research communications, 263(3), 810-815 (1999-10-08)
Metalloproteinase-disintegrins (ADAMs) are type 1 transmembrane proteins that contain a unique domain structure including a zinc-binding metalloproteinase domain. We have isolated cDNAs encoding two novel members of this family, ADAM29 and ADAM30 which show testis-specific expression. Three forms of ADAM29...

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