SAB1408980

Sigma-Aldrich

Monoclonal Anti-EPHB6 antibody produced in mouse

clone 3B6, purified immunoglobulin, buffered aqueous solution

別名:
MGC129910, HEP, MGC129911

品質水準

100

由来生物

mouse

抗体製品の状態

purified immunoglobulin

antibody product type

primary antibodies

クローン

3B6, monoclonal

形態

buffered aqueous solution

分子量

antigen 36.63 kDa

species reactivity

human

アプリケーション

indirect ELISA: suitable
western blot: 1-5 μg/mL

アイソタイプ

IgG2aκ

結合体

unconjugated

NCBIアクセッション番号

UniProtアクセッション番号

出荷済み

dry ice

保管温度

−20°C

Gene Information

human ... EPHB6(2051)

詳細

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands. (provided by RefSeq)

免疫原

EPHB6 (NP_004436, 23 a.a. ~ 122 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
DTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQAEE

物理的形状

無色透明のPBS溶液、pH 7.4

RIDADR

NONH for all modes of transport

ドイツ水質汚染分類

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

試験成績書(COA)
原産地証明書(COO)
Mai Akada et al.
Cellular signalling, 26(12), 2879-2884 (2014-09-23)
Anoikis is a specific type of apoptosis induced by detachment of epithelial cells from extracellular matrix, and acquiring resistance to anoikis is an important step that enables cancer cells to metastasize. EphA2, which is overexpressed in a variety of human...

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