SAB1410844

Sigma-Aldrich

Anti-NNMT antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

由来生物

rabbit

品質水準

100

抗体製品の状態

purified immunoglobulin

antibody product type

primary antibodies

クローン

polyclonal

形態

buffered aqueous solution

分子量

antigen 29.6 kDa

species reactivity

human, mouse

アプリケーション

western blot: 1 μg/mL

結合体

unconjugated

NCBIアクセッション番号

UniProtアクセッション番号

出荷済み

dry ice

保管温度

−20°C

Gene Information

human ... NNMT(4837)

詳細

The nicotinamide N-methyltransferase (NNMT) gene, spanning 16.5kb of genomic DNA with three exons and two introns, is mapped to human chromosome 11q23.1. The encoded protein consists of 264 amino acids with a predicted molecular mass of 29.6kDa. NNMT is expressed in cytoplasm.

免疫原

NNMT (NP_006160.1, 1 a.a. ~ 264 a.a) full-length human protein.

Sequence
MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLSRPL

生物化学的/生理学的作用

Nicotinamide N-methyltransferase (NNMT) is a cytosolic methyltransferase enzyme. It catalyzes the N-methylation of nicotinamide, pyridines and other structural analogs. Hence, it plays a vital role in the biotransformation and detoxification of various xenobiotic compounds. Altered expression of the gene is associated with the pathogenesis of various diseases such as acute lymphoblastic leukemia (ALL), parkinson′s disease, thyroid cancer, gastric cancer, colorectal cancer, lung, liver and oral carcinomas. In addition, variation in the gene might increase the risk of susceptibility to hyperlipidemia and migraine.

物理的形状

無色透明のPBS溶液、pH 7.4

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

ドイツ水質汚染分類

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

試験成績書(COA)
原産地証明書(COO)
Physiological Study on Association between Nicotinamide N-Methyltransferase Gene Polymorphisms and Hyperlipidemia.
Zhu XJ
BioMed Research International (2016)
NNMT (nicotinamide N-methyltransferase)
Emanuelli M
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2009)
Nicotinamide-N-Methyltransferase gene rs694539 variant and migraine risk.
Sazci A
The Journal of Headache and Pain, 17 (2016)

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