SAB2500466

Sigma-Aldrich

抗GJB2/コネキシン26 ヤギ宿主抗体

affinity isolated antibody, buffered aqueous solution

別名:
抗CX26抗体, 抗コネキシン26抗体, 抗ギャップ結合タンパク質抗体
NACRES:
NA.41

品質水準

100

由来生物

goat

抗体製品の状態

affinity isolated antibody

antibody product type

primary antibodies

クローン

polyclonal

形態

buffered aqueous solution

species reactivity

rat, mouse, human

アプリケーション

indirect ELISA: suitable
western blot: suitable

結合体

unconjugated

UniProtアクセッション番号

出荷済み

dry ice

保管温度

−20°C

Gene Information

human ... GJB2(2706)

詳細

Gap junction protein β 2 (GJB2) or connexin 26 (CX26) is a gap junction protein which is part of the connexin (Cx) family. It is expressed in epidermal keratinocytes and cochlea. The protein has four a-helical transmembrane domains, two extracellular loops, a cytoplasmic N-terminal domain and a C-terminal domain. The gene encoding GJB2 consists of two exons and is localized on human chromosome 13q12.

免疫原

NP_003995.2によるタンパク質配列のC末端に由来するペプチド(YLLIRYCSGKSKKP)。

アプリケーション

Anti-GJB2/Connexin 26 antibody produced in goat has been used in Western blotting.

生物化学的/生理学的作用

Gap junction protein β 2 (GJB2) forms hexameric transmembrane channels called connexons, which is vital for gap junction communication. It has a role in the migration of cortical neurons during cortex development. GJB2 is involved in recycling potassium ions which is crucial for the hearing process. Mutations in the gene encoding this protein have been associated with skin disorders and sensorineural hearing loss.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

0.5 mg/mL Tris緩衝生理食塩水(0.5% BSA, 0.02%アジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

ドイツ水質汚染分類

WGK 2

引火点(°F)

Not applicable

引火点(℃)

Not applicable

試験成績書(COA)
原産地証明書(COO)
Revertant mosaicism repairs skin lesions in a patient with keratitis-ichthyosis-deafness syndrome by second-site mutations in connexin 26.
Gudmundsson S
Human Molecular Genetics, 26(6) (2017)
GJB2 Gene Mutations in Syndromic Skin Diseases with Sensorineural Hearing Loss.
Sandra Iossa
Current Genomics (2011)
Non-junctional Cx32 mediates anti-apoptotic and pro-tumor effects via epidermal growth factor receptor in human cervical cancer cells
Yifan Zhao
Cell Death & Disease (2017)
Induction of cell death and gain-of-function properties of connexin26 mutants predict severity of skin disorders and hearing loss.
Press ER
The Journal of Biological Chemistry (2017)
Cell coupling mediated by connexin 26 selectively contributes to reduced adhesivity and increased migration.
Polusani SR
Journal of Cell Science (2016)

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