SAB2500475

抗GOT2(アミノ酸295-306)抗体 ヤギ宿主抗体

affinity isolated antibody, buffered aqueous solution

• Synonym(s): 抗FLJ40994抗体, 抗アスパラギン酸アミノトランスフェラーゼ2抗体, 抗グルタミン酸オキサロ酢酸トランスアミナーゼ2抗体
• NACRES: NA.41

Properties

• 由来生物: goat
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• antibody product type: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• species reactivity: rat, mouse, human
• technique(s): indirect ELISA: suitable; western blot: suitable
• UniProtアクセッション番号: P00505
• 輸送温度: dry ice
• 保管温度: −20°C
• Gene Information: human ... GOT2(2806)

Description

詳細

The GOT2 (glutamic-oxaloacetic transaminase 2) gene is mapped to human chromosome 16q21 and the encoded protein is localized to mitochondria.

免疫原

NP_002071.2によるタンパク質配列の内部領域に由来するペプチド(CKDADEAKRVES)。

生物化学的／生理学的作用

GOT2 (glutamic-oxaloacetic transaminase 2) participates in malate–aspartate shuttle, which increases the rate of glycolysis via cytosolic NADH (nicotinamide adenine dinucleotide) transfer into mitochondria. This supports rapid growth in tumor cell. GOT2 catalyzes the transamination reaction involving oxaloacetate and L-glutamate to give rise to aspartate, also generating α-ketoglutarate in mitochondria. Aspartate, that is formed, serves as a precursor of N-acetylaspartate, a predominantly abundant free amino acid found in the brain.

特徴および利点

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物理的形状

0.5 mg/mL Tris緩衝生理食塩水(0.5% BSA, 0.02%アジ化ナトリウム含有)。

Safety Information

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315 - H319
• 注意書き: P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable