SAB2501049

Sigma-Aldrich

抗TOM1L1/SRCASM抗体 ヤギ宿主抗体

affinity isolated antibody, buffered aqueous solution

別名:
抗myb1標的(TOM)(ニワトリ)様1抗体, 抗myb1標的(TOM)様1抗体, 抗SRCASM抗体
NACRES:
NA.41

品質水準

100

由来生物

goat

抗体製品の状態

affinity isolated antibody

antibody product type

primary antibodies

クローン

polyclonal

形態

buffered aqueous solution

species reactivity

human

アプリケーション

indirect ELISA: suitable
western blot: suitable

結合体

unconjugated

UniProtアクセッション番号

出荷済み

dry ice

保管温度

−20°C

Gene Information

human ... TOM1L1(10040)

詳細

The gene TOM1L1 (target of myb1 like 1 membrane trafficking) is mapped to human chromosome 17q23.(5) The protein has a VHS (Vps27p/Hrs/Stam) domain at the N-terminal, a GAT (GGA (Golgi-localizing, ?-adaptin ear domain homology, ADP-ribosylation factor (Arf)-binding protein and Tom) domain at the center and interaction motifs at the C-terminal.1,2

免疫原

NP_005477.1によるタンパク質配列の内部領域に由来するペプチド(C-EQNKNQKEATNTTSE)。

生物化学的/生理学的作用

TOM1L1 (target of myb1 like 1 membrane trafficking) is an adaptor protein, which is involved in vesicular trafficking as well as intracellular signaling. It negatively controls the mitogenic and transforming functions in fibroblasts by working as a substrate for SRC (tyrosine protein kinase).1,2 It is involved in EGF (epidermal growth factor)-mediated internalization of EGF receptor.4 TOM1L1 is downregulated in cutaneous squamous cell carcinoma and esophageal squamous cell carcinoma.3

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

Tris緩衝生理食塩水(0.5% BSA, 0.02%アジ化ナトリウム含有)の0.5 mg/mL溶液。

ピクトグラム

Exclamation mark

シグナルワード

Warning

危険有害性情報

注意書き

RIDADR

NONH for all modes of transport

ドイツ水質汚染分類

WGK 2

引火点(°F)

Not applicable

引火点(℃)

Not applicable

試験成績書(COA)
原産地証明書(COO)
Béatrice Orsetti et al.
Cancer research, 64(18), 6453-6460 (2004-09-18)
Chromosome 17 is severely rearranged in breast cancer. Whereas the short arm undergoes frequent losses, the long arm harbors complex combinations of gains and losses. In this work we present a comprehensive study of quantitative anomalies at chromosome 17 by...
Ning Sheng Liu et al.
The EMBO journal, 28(22), 3485-3499 (2009-10-03)
Although many proteins have been shown to participate in ligand-stimulated endocytosis of EGF receptor (EGFR), the adaptor protein responsible for interaction of activated EGFR with endocytic machinery remains elusive. We show here that EGF stimulates transient tyrosine phosphorylation of Tom1L1...
Audrey Sirvent et al.
Molecular & cellular proteomics : MCP, 11(12), 1937-1950 (2012-10-02)
The non-receptor tyrosine kinase SRC is frequently deregulated in human colorectal cancer (CRC), and SRC increased activity has been associated with poor clinical outcomes. In nude mice engrafted with human CRC cells, SRC over-expression favors tumor growth and is accompanied...
Yu Qi et al.
Anticancer research, 30(9), 3535-3539 (2010-10-15)
Src-family tyrosine kinases (SFKs) play critical roles in regulating cellular differentiation and proliferation. Src-activating and signaling molecule (Srcasm) is a novel molecule that down-regulates SFK activity and promotes cell differentiation. The aim of this study was to determine whether Srcasm...
Ahmed Elmarghani et al.
Mediators of inflammation, 2009, 416298-416298 (2010-02-26)
TOM1L (target of Myb-1 Like) was identified as a binding partner for the full length and catalytically-active Lck in a yeast 2-hybrid screening assay. Here we show that in Jurkat T cells stimulated by CD3/CD28 coligation where the expression of...

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