SAB2501420

Sigma-Aldrich

Anti-PEBP4 (C-terminal) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

別名:
Anti-CORK-1, Anti-CORK1, Anti-GWTM1933, Phosphatidylethanolamine-binding protein 4, Anti-MGC22776
NACRES:
NA.41

品質水準

100

由来生物

goat

抗体製品の状態

affinity isolated antibody

antibody product type

primary antibodies

クローン

polyclonal

形態

buffered aqueous solution

species reactivity

human

アプリケーション

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

結合体

unconjugated

UniProtアクセッション番号

出荷済み

dry ice

保管温度

−20°C

Gene Information

human ... PEBP4(157310)

詳細

The gene PEBP4 (phosphatidylethanolamine binding protein 4) is mapped to human chromosome 8p21.3. It belongs to the PEBP family of proteins. The protein has potential glycosylation sites and can be secreted. It is mainly expressed in the skeletal muscle, heart and thyroid.

免疫原

Peptide with sequence RERASEPKHKNQAE, from the C-terminal region of the protein sequence according to NP_659399.2

生物化学的/生理学的作用

PEBP4 (phosphatidylethanolamine binding protein 4) regulates apoptosis by associating with Raf1 (proto-oncogene serine/threonine-protein kinase) and MEK1 (MAPK/ERK kinase 1). This association blocks TNFα (tumor necrosis α) or TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) - mediated activation of MEK/ERK (extracellular signal-regulated kinase). PEBP4 is also involved in myoblast differentiation. Additionally, it promotes Akt (RAC-α serine/threonine-protein kinase) activation. The gene is expressed in various cancers and is associated with cancer progression. The PEBP4 mRNA is a target of microRNA miR-34a.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

20mM Tris(pH 7.3)、150mM NaCl、0.02% アジ化ナトリウム、0.5% ウシ血清アルブミン含有)を含む溶液中に0.5 mg/mLの濃度で提供されます。

RIDADR

NONH for all modes of transport

ドイツ水質汚染分類

WGK 2

引火点(°F)

Not applicable

引火点(℃)

Not applicable

試験成績書(COA)
原産地証明書(COO)
L Somashekar et al.
Andrology, 5(5), 1032-1051 (2017-09-01)
This study aimed to identify sperm proteomic signatures regulating sperm functions and fertility by: (i) comparing the sperm electrophoretic protein profiles and identifying the differentially abundant proteins among breeding bulls differing in fertility status and (ii) elucidating the possible role...
Huan He et al.
Biochimica et biophysica acta, 1863(7 Pt A), 1682-1689 (2016-04-02)
Phosphatidylethanolamine binding proteins (PEBP) represent a superfamily of proteins that are conserved from bacteria to humans. In mammals, four members have been identified, PEBP1-4. To determine the functional differences among PEBP1-4 and the underlying mechanism for their actions, we performed...
Li Chushi et al.
Gene, 587(1), 42-47 (2016-04-18)
Alteration of metabolic profile is one of the hallmarks of cancer cells. Statin, the inhibitors for synthesis of cholesterol, has shown anti-cancer effects on the gastric cancer cells. However, the functions of its target, HMGCR, in the progression of gastric...
Guiping Yu et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(10), 10341-10349 (2014-07-21)
The aim of this study was to determine the relationship and underlying mechanisms between ectopic expression of phosphatidylethanolamine-binding protein 4 (PEBP4) and cisplatin (DDP)-induced cytotoxicity in the lung cancer cell line A549 to provide an experimental basis for future chemotherapeutic...

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