SAB2501623

Anti-SFRP1 (C-terminal) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

• Synonym(s): 抗FRP抗体
• NACRES: NA.41

Properties

• 由来生物: goat
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• antibody product type: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• species reactivity: mouse, human, bovine
• technique(s): immunohistochemistry: suitable; indirect ELISA: suitable
• UniProtアクセッション番号: Q8N474
• 輸送温度: dry ice
• 保管温度: −20°C
• Gene Information: human ... SFRP1(6422)

Description

詳細

The gene SFRP1 (secreted frizzled related protein 1) is mapped to human chromosome 8p22–p12, a region frequently deleted in breast cancer. It is highly expressed in normal breast tissue.

免疫原

Peptide with sequence KNHECPTFQSVFK, from the C-terminal region of the protein sequence according to NP_003003.3

包装

100 μg

生物化学的／生理学的作用

Secreted Frizzled-related protein 1 (SFRP1) is a secreted inhibitor of Wnt signaling pathway. DNA damage or oxidative stress causes cellular senescence, which leads to the overexpression of sfrp1. This protein induces senescence phenotypes via the inactivation of Wnt signaling and activation of the retinoblastoma (Rb) pathway. Mutations or aberrant methylation in this gene impair the induction of senescence in several cancers, including breast cancer, bladder cancer, and colorectal tumorigenesis.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

20mM Tris（pH 7.3）、150mM NaCl、0.02％ アジ化ナトリウム、0.5％ ウシ血清アルブミン含有）を含む溶液中に0.5 mg/mLの濃度で提供されます。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable