SAB2702325

Sigma-Aldrich

Monoclonal Anti-CXCR2 antibody produced in mouse

clone GT547, affinity isolated antibody

別名:
IL8R2, CDw128b, CD182, CMKAR2
NACRES:
NA.41

品質水準

100

由来生物

mouse

抗体製品の状態

affinity isolated antibody

antibody product type

primary antibodies

クローン

GT547, monoclonal

形態

buffered aqueous solution

分子量

41kDa

species reactivity

human

濃度

1mg/mL

アプリケーション

immunofluorescence: 1:100-1:1,000
western blot: 1:1,000-1:10,000

アイソタイプ

IgG2a

結合体

unconjugated

UniProtアクセッション番号

出荷済み

wet ice

保管温度

−20°C

Gene Information

human ... CXCR2(3579)

免疫原

Recombinant protein encompassing a sequence within the N-terminus region of human CXCR2.

アプリケーション

Suggested starting dilutions are as follows: WB: 1:1000-1:10000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

生物化学的/生理学的作用

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq]

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

その他情報

Purification: Affinity purified by Protein A

物理的形状

Phosphate-buffered saline, no preservative added.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

ドイツ水質汚染分類

WGK 1

引火点(°F)

Not applicable

引火点(℃)

Not applicable

試験成績書(COA)
原産地証明書(COO)

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