Merck

SAB3500428

Sigma-Aldrich

Anti-DR4 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

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別名:
Anti-TRAIL-R1
MDL番号:
NACRES:
NA.41

由来生物

rabbit

品質水準

結合体

unconjugated

抗体製品の状態

IgG fraction of antiserum

antibody product type

primary antibodies

クローン

polyclonal

形状

buffered aqueous solution

分子量

predicted mol wt 56 kDa

species reactivity

human

technique(s)

immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBIアクセッション番号

UniProtアクセッション番号

輸送温度

dry ice

保管温度

−20°C

target post-translational modification

unmodified

Gene Information

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当該品目
SAB4700541SAB3500427WH0008795M1
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

clone

polyclonal

clone

DR-4-02, monoclonal

clone

polyclonal

clone

2D6, monoclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

mol wt

predicted mol wt 56 kDa

mol wt

-

mol wt

-

mol wt

-

詳細

Soluble tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 (sTRAIL-R1), also known as DR4, is encoded by the gene mapped to human chromosome 8p21-22. It belongs to the TNFR superfamily of transmembrane proteins. TRAIL-R1 contains a cytoplasmic "death domain," which can activate the cell′s apoptotic machinery. TRAIL receptor-1/DR4 is activated by binding to either membrane anchored or soluble TRAIL/Apo2L.

免疫原

DR4 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DR4 protein.

アプリケーション

Anti-DR4 antibody produced in rabbit has been used in western blotting.

生物化学的/生理学的作用

Soluble tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 (sTRAIL-R1) interacts with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and stimulates cell-death signaling pathway. Mutation of the sTRAIL-R1 gene is associated with the pathogenesis of non-Hodgkin′s lymphoma (NHL). In addition, variation of TRAIL-R1 also increases the risk of susceptibility to prostate cancer (PCa) in North Indian population.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

関連事項

The action of this antibody can be blocked using blocking peptide SBP3500428.

物理的形状

PBS(0.02% アジ化ナトリウム含有)

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

関連製品

製品番号
詳細
価格

保管分類コード

10 - Combustible liquids

WGK

WGK 2

引火点(°F)

Not applicable

引火点(℃)

Not applicable


Certificates of Analysis (COA)

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  • もしTO09019TOなどのロット番号を見つけた場合は、最初の2文字を除いたロット番号09019TOを入力します。

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COAをリクエストする

The role of TRADD in death receptor signaling.
Pobezinskaya YL and Liu Z
Cell Cycle (2012)
Somatic mutations of TRAIL-receptor 1 and TRAIL-receptor 2 genes in non-Hodgkin's lymphoma.
Lee SH
Oncogene (2001)
Death receptor 4 variants enhanced prostate cancer risk in North Indian population.
Mittal RD
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine (2015)
DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells*
Tianliang Li
The Journal of Biological Chemistry (2015)
Tianliang Li et al.
The Journal of biological chemistry, 290(17), 11108-11118 (2015-03-15)
TNFRSF10A and TNFRSF10B are cell surface receptors that bind to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and mediate the extrinsic pathway of apoptosis. However, the mechanisms of transcriptional regulation of TNFRSF10A and TNFRSF10B remain largely uncharacterized. In this study, two

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