Interleukin-36 (IL-36) ligands require processing for full agonist agonist (IL-36a, IL-36b, and IL-36g) or antagonist (IL-36Ra) activity
Towne JE, et al
The Journal of Biological Chemistry, 286, 42954-42602 (2011)
Solenne Vigne et al.
Blood, 120(17), 3478-3487 (2012-09-13)
The interleukin-1 (IL-1) superfamily of cytokines comprises a set of pivotal mediators of inflammation. Among them, the action of IL-36 cytokines in immune responses has remained elusive. In a recent study, we demonstrated a direct effect of IL-36 on immune...
D E Smith et al.
The Journal of biological chemistry, 275(2), 1169-1175 (2000-01-08)
We report here the cloning and characterization of four new members of the interleukin-1 (IL-1) family (FIL1delta, FIL1epsilon, FIL1zeta, and FIL1eta, with FIL1 standing for "Family of IL-1"). The novel genes demonstrate significant sequence similarity to IL-1alpha, IL-1beta, IL-1ra, and...
Jennifer E Towne et al.
The Journal of biological chemistry, 279(14), 13677-13688 (2004-01-22)
Interleukin 1 (IL-1) plays a prominent role in immune and inflammatory reactions. Our understanding of the IL-1 family has recently expanded to include six novel members named IL-1F5 to IL-1F10. Recently, it was reported that IL-1F9 activated NF-kappaB through the...