Merck
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SAB4200803

Sigma-Aldrich

Anti-TFE3 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):
Anti-Class E basic helix-loop-helix protein 33, Anti-Transcription factor E3, Anti-bHLHe33
NACRES:
NA.41

由来生物

rabbit

抗体製品の状態

affinity isolated antibody

antibody product type

primary antibodies

クローン

polyclonal

形態

buffered aqueous solution

分子量

~60 kDa

species reactivity

human, mouse

包装

antibody small pack of 25 μL

濃度

~1.0 mg/mL

technique(s)

immunoblotting: 4-8 μg/mL using human HeLa cells extract
immunofluorescence: 2.5-5 μg/mL using mouse embryo fibroblast NIH-3T3 cells

UniProtアクセッション番号

輸送温度

dry ice

保管温度

−20°C

Gene Information

human ... TFE3(7030)

Related Categories

詳細

Transcription factor E3 (TFE3), also known as Class E basic helix-loop-helix protein 33 (bHLHe33), is a transcriptional activator that mediates the enhancer-promoter interactions. TFE3 belongs to the MiT family of helix-loop-helix leucine zipper transcription factors, it is ubiquitously expressed and can directly associate with DNA as either homodimer or heterodimer formed with two other MiT family members, TFEB or TFEC. TFE3 serves an important role in cell growth, cell proliferation, in cellular adaptation to starvation and cellular response to ER stress. Under nutrient-rich conditions TFE3 is located in the cytoplasm, under starvation conditions or treatment with ER stressors, TFE3 rapidly translocated to nuclear, there it mediates cellular adaptation to stress by simultaneously promoting lysosomal biogenesis, autophagy induction, as well as expression of critical mitochondrial and metabolic regulators. TFE3 has been shown to participate in the transcriptional regulation of the innate immune response. in addition, it was demonstrated that pathogen infections promote TFE3 nuclear translocation, thus inducing the expression of several cytokines and chemokines.

Anti-TFE3 antibody specifically recognizes TFE3 from human and mouse origin.

免疫原

Synthetic peptide corresponding to the human TFE3

アプリケーション

The antibody may be used in various immunochemical techniques including Immunoblotting (∼60 kDa) and Immunofluorescence. Detection of the TFE3 band by Immunoblotting is specifically inhibited by the immunizing peptide.

物理的形状

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

その他情報

This product is for R&D use only, not for drug, household, or other uses.

保管分類コード

12 - Non Combustible Liquids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

Certificate of Analysis

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Certificate of Origin

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