SAB4300676

Sigma-Aldrich

抗ビメンチン ウサギ宿主抗体

affinity isolated antibody

別名:
抗VIM抗体
NACRES:
NA.41

由来生物

rabbit

品質水準

100

抗体製品の状態

affinity isolated antibody

antibody product type

primary antibodies

クローン

polyclonal

形態

buffered aqueous solution

分子量

~57 kDa

species reactivity

mouse, human, rat, monkey

濃度

1 mg/mL

アプリケーション

western blot: 1:500-1:1000

アイソタイプ

IgG

免疫原配列

(G-Q-V-I-N)

結合体

unconjugated

NCBIアクセッション番号

出荷済み

wet ice

保管温度

−20°C

Gene Information

human ... Vimentin(7431)

詳細

Vimentin is a specific type III intermediate filament (IF) protein. It is abundantly expressed in mesenchymal cells. It is located on human chromosome 10p13.

The antibody detects endogenous level of total Vimentin protein.

免疫原

Peptide sequence around aa. 452-456 (G-Q-V-I-N), according to the protein NP_003371.2

生物化学的/生理学的作用

Vimentin helps to preserve the structure of cell and stability of tissue in mesenchymal cells. It is involved in tumorigenesis, EMT (epithelial mesenchymal transition) and the metastatic spread of cancer. It also controls infectious internalization of human papillomavirus 16 pseudovirions.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

ターゲットの説明

Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells.

物理的形状

PBS(0.02% アジ化ナトリウム、50% グリセロール含有)

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

storage_class_code

12 - Non Combustible Liquids

ドイツ水質汚染分類

WGK 1

引火点(°F)

Not applicable

引火点(℃)

Not applicable

試験成績書(COA)

原産地証明書(COO)

The gene encoding human vimentin is located on the short arm of chromosome 10
Ferrari S, et al.
American Journal of Human Genetics (1987)
Esther Natalia Muñoz et al.
Biochemistry and biophysics reports, 27, 101027-101027 (2021-06-24)
ROCK2 is a protein involved in the restructuring of the cytoskeleton in cell adhesion and contractibility processes. miR-138-5p and miR-455-3p regulate Rock2 expression, cell proliferation, migration, and invasion in different experimental cell models. However, their participation in the cytoarchitecture and...
Viscoelastic properties of vimentin compared with other filamentous biopolymer networks
Janmey PA, et al.
The Journal of Cell Biology (1991)
Vimentin Modulates Infectious Internalization of Human Papillomavirus 16 Pseudovirions
Schafer G, et al.
Journal of Virology (2017)
Vimentin is a potential prognostic factor for tongue squamous cell carcinoma among five epithelial-mesenchymal transition-related proteins
Liu PF, et al.
PLoS ONE (2017)

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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