SAB4503081

Sigma-Aldrich

抗ビメンチン ウサギ宿主抗体

affinity isolated antibody

別名:
VIME, vimentin
NACRES:
NA.41

由来生物

rabbit

品質水準

100

抗体製品の状態

affinity isolated antibody

antibody product type

primary antibodies

クローン

polyclonal

形態

buffered aqueous solution

分子量

antigen 53 kDa

species reactivity

mouse, human, rat

濃度

~1 mg/mL

アプリケーション

ELISA: 1:10000
western blot: 1:500-1:1000

結合体

unconjugated

NCBIアクセッション番号

UniProtアクセッション番号

出荷済み

wet ice

保管温度

−20°C

Gene Information

human ... VIM(7431)

詳細

Anti-Vimentin Antibody detects endogenous levels of total Vimentin protein.
The VIM (vimentin) gene codes for an intermediate filament protein, that is expressed throughout mesenchymal cells. VIM gene is mapped to human chromosome 10p13.

免疫原

The antiserum was produced against synthesized peptide derived from human Vimentin.

Immunogen Range: 56-105

生物化学的/生理学的作用

Vimentin is known to promote epithelial to mesenchymal transition and contributes to metastasis in cancer such as ovarian cancer. Vimentin preserves cellular structure and tissue integrity. Vimentin is also known to bring about TNF-α (tumor necrosis factor-α) induced cell apoptosis.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

ウサギIgGのPBS溶液(Mg2+およびCa2+を含まず)、pH 7.4、150 mM NaCl、0.02% アジ化ナトリウム、50% グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

storage_class_code

12 - Non Combustible Liquids

ドイツ水質汚染分類

nwg

引火点(°F)

Not applicable

引火点(℃)

Not applicable

試験成績書(COA)

原産地証明書(COO)

Jingyin Han et al.
Medical science monitor : international medical journal of experimental and clinical research, 27, e927978-e927978 (2021-06-16)
BACKGROUND Pneumoconiosis is a chronic progressive fibrotic interstitial pneumonia for which the pathogenesis and treatment remain unclear. Previous studies showed that sodium ferulate (SF) may have a therapeutic effect, and this study explored the mechanism underlying SF-related improvement. MATERIAL AND...
Toshiaki Miyazaki et al.
Oncogenesis, 7(1), 7-7 (2018-01-25)
The antitumor immune response is a critical defense system that eliminates malignant cells. The failure of the system results in immune escape and proceeds to tumor growth. We have previously showed that estrogen receptor-binding fragment-associated antigen 9 (EBAG9) is a...
The ubiquitin ligase TRIM56 inhibits ovarian cancer progression by targeting vimentin.
Zhao L, et al.
Journal of Cellular Physiology (2018)
Tumor HLA?DR expression linked to early intrahepatic recurrence of hepatocellular carcinoma
Matoba K, et al.
International Journal of Cancer. Journal International Du Cancer, 115(2), 231-240 (2005)
Lifeng Yang et al.
Toxicology, 389, 74-84 (2017-07-27)
Both RhoA/ROCK and Raf-1/CK2 pathway play essential roles in cell proliferation, apoptosis, differentiation, and multiple other common cellular functions. We previously reported that vimentin is responsible for TNF-α-induced cell apoptosis. Herein, we investigated the regulation of RhoA/ROCK and Raf-1/CK2 signaling...

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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