Merck

SML0053

Sigma-Aldrich

CP-101,606

≥98% (HPLC)

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別名:
トラキソプロジル; (1S,2S)-1-(4-ヒドロキシ-フェニル)-2-(4-ヒドロキシ-4-フェニルピペリジノ)-1-プロパノール; CP-101606
Empirical Formula (Hill Notation):
C20H25NO3
CAS番号:
分子量:
327.42
MDL番号:
PubChem Substance ID:
NACRES:
NA.77

品質水準

アッセイ

≥98% (HPLC)

形状

powder

光学活性

[α]/D +50 to +60° (c=1, MeOH)

white to tan

溶解性

DMSO: ≥35 mg/mL

オーガナイザー

Pfizer

保管温度

2-8°C

SMILES string

C[C@@H]([C@@H](O)c1ccc(O)cc1)N2CCC(O)(CC2)c3ccccc3

InChI

1S/C20H25NO3/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17/h2-10,15,19,22-24H,11-14H2,1H3/t15-,19+/m0/s1

Inchi Key

QEMSVZNTSXPFJA-HNAYVOBHSA-N

Gene Information

関連するカテゴリー

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当該品目
PZ0255SML0752PZ0124
CP-101,606 ≥98% (HPLC)

Sigma-Aldrich

SML0053

CP-101,606

CP-101606 mesylate ≥98% (HPLC)

Sigma-Aldrich

PZ0255

CP-101606 mesylate

CP-66713 ≥98% (HPLC)

Sigma-Aldrich

PZ0124

CP-66713

form

powder

form

powder

form

powder

form

powder

color

white to tan

color

white to beige

color

white to beige

color

white to off-white

solubility

DMSO: ≥35 mg/mL

solubility

DMSO: 20 mg/mL, clear

solubility

H2O: 15 mg/mL, clear

solubility

DMSO: ≥5 mg/mL

originator

Pfizer

originator

Pfizer

originator

-

originator

Pfizer

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

詳細

CP-101,606 (Traxoprodil) is a substituted 4-phenylpiperidine and is localized in the fore brain neurons.

アプリケーション

CP-101,606 has been used as a N-methyl-D-aspartate (NMDA) receptor antagonist to study its role in recovery of spinal cord injuries.

生物化学的/生理学的作用

トラキソプロジル(CP-101,606)はN-メチル-D-アスパラギン酸(NMDA)受容体の強力な非競合的拮抗薬で、NR2Bサブユニットに選択的に作用します。脳損傷および脳卒中の動物モデルで、神経保護作用をもつことが明らかになっています。
CP-101,606 (Traxoprodil) plays a role in inhibiting glutamate-induced death in rats. It may exhibit therapeutic effects against human ischemia and neurodegenerative disorders. Traxoprodil is metabolized by cytochrome P450 (CYP) 2D6.

特徴および利点

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable


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製品番号
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25G
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705578-5MG-PW

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1000309185

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  • もしTO09019TOなどのロット番号を見つけた場合は、最初の2文字を除いたロット番号09019TOを入力します。

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Chandra Prakash et al.
Drug metabolism and disposition: the biological fate of chemicals, 35(8), 1350-1364 (2007-05-15)
Disposition of traxoprodil ({1-[2-hydroxy-2-(4-hydroxy-phenyl)-1-methyl-ethyl]-4-phenyl-piperidin-4-ol}mesylate; TRX), a selective antagonist of the N-methyl-d-aspartate class of glutamate receptors, was investigated in rats and dogs after administration of a single i.v. bolus dose of [(14)C]TRX. Total mean recoveries of the radiocarbon were 92.5 and
Timothy J Taylor et al.
Clinical pharmacokinetics, 45(10), 989-1001 (2006-09-21)
Traxoprodil, a substituted 4-phenylpiperidine, is an N-methyl-D-aspartate (NMDA) receptor antagonist that is selective for receptors containing the NR2B subunit. In vivo and in vitro studies examining the disposition of traxoprodil have demonstrated that it is mainly metabolised by cytochrome P450
Robert Becker et al.
Psychopharmacology, 236(12), 3451-3463 (2019-07-04)
The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine is known to have not only a rapid antidepressant effect but also dissociative side effects. Traxoprodil and lanicemine, also NMDA antagonists, are candidate antidepressant drugs with fewer side effects. In order to understand their
Weronika Stasiuk et al.
Journal of neural transmission (Vienna, Austria : 1996), 124(3), 387-396 (2016-12-03)
Pre-clinical and clinical studies indicated that a blockade of the NMDA receptor complex creates new opportunities for the treatment of affective disorders, including depression. The aim of the present study was to assess the influence of traxoprodil (10 mg/kg) on the
Bo Chen et al.
Cell, 174(3), 521-535 (2018-07-24)
Many human spinal cord injuries are anatomically incomplete but exhibit complete paralysis. It is unknown why spared axons fail to mediate functional recovery in these cases. To investigate this, we undertook a small-molecule screen in mice with staggered bilateral hemisections

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